Issue 36, 2005
From the journal:

Chemical Communications

Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients†

Peddy Vishweshwar,a   Jennifer A. McMahon,a   Matthew L. Peterson,b   Magali B. Hickey,b   Tanise R. Shattocka  and  Michael J. Zaworotko*a  

* Corresponding authors

a Department of Chemistry, University of South Florida, SCA 400, 4202 E. Fowler Avenue, Tampa, Florida, USA
E-mail: xtal@usf.edu
Fax: +1 813 974 3203
Tel: +1 813 974 4129

b TransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, Massachusetts, USA

Abstract

The carboxylic acid–primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.

Graphical abstract: Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients

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Article information

DOI
https://doi.org/10.1039/B501304F
Article type
Communication
Submitted
25 Jan 2005
Accepted
18 Jul 2005
First published
15 Aug 2005

Chem. Commun., 2005, 4601-4603

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Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients

P. Vishweshwar, J. A. McMahon, M. L. Peterson, M. B. Hickey, T. R. Shattock and M. J. Zaworotko, Chem. Commun., 2005, 4601 DOI: 10.1039/B501304F

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