Issue 20, 2005
From the journal:

Chemical Communications

Artificial metallonucleases

Fabrizio Mancin,a   Paolo Scrimin,a   Paolo Tecillab  and  Umberto Tonellatoa  

a Dipartimento di Scienze Chimiche and Istituto CNR di Tecnologia delle Membrane - Sezione di Padova, Università di Padova, via Marzolo 1, I-35131 Padova, Italy
E-mail: fabrizio.mancin@unipd.it; paolo.scrimin@unipd.it; umberto.tonellato@unipd.it
Fax: +39 0498275239
Tel: +39 0498275276-5269

b Dipartimento di Scienze Chimiche, Università di Trieste, via Giorgieri 1, I-34127 Trieste, Italy
E-mail: tecilla@dsch.univ.trieste
Fax: +39 0405583903
Tel: +39 0405583925

Abstract

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.

Graphical abstract: Artificial metallonucleases

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Article information

DOI
https://doi.org/10.1039/B418164F
Article type
Feature Article
Submitted
02 Dec 2004
Accepted
25 Jan 2005
First published
22 Feb 2005

Chem. Commun., 2005, 2540-2548

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Artificial metallonucleases

F. Mancin, P. Scrimin, P. Tecilla and U. Tonellato, Chem. Commun., 2005, 2540 DOI: 10.1039/B418164F

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