Issue 8, 2004
From the journal:

Analyst

Analysis of corticosteroids by high performance liquid chromatography–electrospray mass spectrometry

Alessia Panusa,a   Monica Ottaviani,b   Mauro Picardo,b   Emanuela Camera,b   Luigi Gagliardi,a   Paola Chimenti,c   Arianna Granesec  and  Domenica Tonelli*d  

* Corresponding authors

a Laboratorio di Chimica del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy

b Laboratorio di Fisiopatologia Cutanea, Istituto Dermatologico, San Gallicano, Rome, Italy

c Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università la Sapienza, Rome, Italy

d Dipartimento di Chimica Fisica ed Inorganica, Università degli Studi di Bologna, Viale Risorgimento 4, 40136 Bologna, Italy

Abstract

A high performance liquid chromatography electrospray mass spectrometry (HPLC-ESI-MS) method, for the detection of corticosteroids in cosmetics has been developed. A water–acetonitrile linear gradient on a C-18 reversed-phase column was found to be suitable in separating triamcinolone and its main derivatives, which greatly differ in lipophilicity. Detection was performed in negative electrospray ionisation mode. Good correlation between peaks areas and solutions concentration was found in the range 0.05–10.0 µg ml−1 and the detection limits resulted in the range of 20–45 pg injected. The method was successfully applied to the analysis of real samples of shampoo.

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Article information

DOI
https://doi.org/10.1039/B402905D
Article type
Paper
Submitted
25 Feb 2004
Accepted
25 May 2004
First published
06 Jul 2004

Analyst, 2004,129, 719-723

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Analysis of corticosteroids by high performance liquid chromatography–electrospray mass spectrometry

A. Panusa, M. Ottaviani, M. Picardo, E. Camera, L. Gagliardi, P. Chimenti, A. Granese and D. Tonelli, Analyst, 2004, 129, 719 DOI: 10.1039/B402905D

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