Volume 128, 2005
From the journal:

Faraday Discussions

Peptide mediated formation of hierarchically organized solution and solid state polymer nanostructures

Harm-Anton Klok,*a   Guido W. M. Vandermeulen,b   Harald Nuhn,a   Annette Rösler,b   Ian W. Hamley,c   Valeria Castelletto,c   Hui Xud  and  Sergei S. Sheikod  

* Corresponding authors

a École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux, Laboratoire des Polymères, Bâtiment MX-D, Lausanne, Switzerland
E-mail: harm-anton.klok@epfl.ch.
Fax: ++41 21 693 5650

b Max Planck Institute for Polymer Research Ackermannweg 10, Mainz, Germany

c Department of Chemistry, University of Leeds, Leeds, UK

d Department of Chemistry, CB# 3290 University of North Carolina at Chapel Hill, Chapel Hill, USA

Abstract

Biologically-inspired peptide sequences have been explored as auxiliaries to mediate self-assembly of synthetic macromolecules into hierarchically organized solution and solid state nanostructures. Peptide sequences inspired by the coiled coil motif and “switch” peptides, which can adopt both amphiphilic α-helical and β-strand conformations, were conjugated to poly(ethylene glycol) (PEG). The solution and solid state self-assembly of these materials was investigated using a variety of spectroscopic, scattering and microscopic techniques. These experiments revealed that the folding and organization properties of the peptide sequences are retained upon conjugation of PEG and that they provide the driving force for the formation of the different nanoscale structures which were observed. The possibility of using defined peptide sequences to direct structure formation of synthetic polymers together with the potential of peptide sequences to induce a specific biological response offers interesting prospects for the development of novel self-assembled and biologically active materials.

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Article information

DOI
https://doi.org/10.1039/B402273D
Article type
Paper
Submitted
16 Feb 2004
Accepted
02 Apr 2004
First published
13 Sep 2004

Faraday Discuss., 2005,128, 29-41

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Peptide mediated formation of hierarchically organized solution and solid state polymer nanostructures

H. Klok, G. W. M. Vandermeulen, H. Nuhn, A. Rösler, I. W. Hamley, V. Castelletto, H. Xu and S. S. Sheiko, Faraday Discuss., 2005, 128, 29 DOI: 10.1039/B402273D

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