Issue 2, 2003
From the journal:

Natural Product Reports

Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis

Ken-ichi Kimuraa  and  Timothy D. H. Buggb  

a Department of Agro-Bioscience, Iwate University, Iwate 020-8550, Japan

b Department of Chemistry, University of Warwick, Coventry, UK

Abstract

Covering: Until September 2002

The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin.

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Article information

DOI
https://doi.org/10.1039/B202149H
Article type
Review Article
Submitted
19 Nov 2002
First published
03 Mar 2003

Nat. Prod. Rep., 2003,20, 252-273

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Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis

K. Kimura and T. D. H. Bugg, Nat. Prod. Rep., 2003, 20, 252 DOI: 10.1039/B202149H

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