Issue 3, 2002
From the journal:

Chemical Communications

Rapid assembly of highly-functionalised difluorinated cyclooctenones viaring-closing metathesis

Benson M. Kariuki,a   W. Martin Owton,b   Jonathan M. Percy,†*a   Stéphane Pintat,†a   Clive A. Smith,c   Neil S. Spencer,a   Andrew C. Thomasa  and  Martin Watsona  

* Corresponding authors

a School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK

b Lilly Research Centre Ltd., Erl Wood Manor, Windlesham, Surrey, UK

c GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, UK

Abstract

Building block methodology from trifluoroethanol and ring-closing metathesis using a Fürstner modification of Grubbs′ conditions allows the rapid synthesis of novel difluorinated cyclooctenones.

Graphical abstract: Rapid assembly of highly-functionalised difluorinated cyclooctenones via ring-closing metathesis

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Article information

DOI
https://doi.org/10.1039/B109651F
Article type
Communication
Submitted
23 Oct 2001
Accepted
22 Nov 2001
First published
16 Jan 2002

Chem. Commun., 2002, 228-229

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Rapid assembly of highly-functionalised difluorinated cyclooctenones via ring-closing metathesis

B. M. Kariuki, W. M. Owton, J. M. Percy, S. Pintat, C. A. Smith, N. S. Spencer, A. C. Thomas and M. Watson, Chem. Commun., 2002, 228 DOI: 10.1039/B109651F

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