Issue 21, 2001
From the journal:

Journal of the Chemical Society, Dalton Transactions

Dimeric yttrium(iii) and neodymium(iii) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA

S. W. Annie Bligh,*a   Nick Choi,a   Evagoras G. Evagorou,a   Mary McPartlina  and  Kenneth N. Whitea  

* Corresponding authors

a School of Biological and Applied Sciences, University of North London, Holloway Road, London, UK
E-mail: a.bligh@unl.ac.uk

Abstract

Dimeric complexes of macrocycle L, [{ML(OH)(H2O)}2](NO3)4 where M = Y and Nd, have been prepared via template synthesis. X-Ray structural analysis of [{YL(OH)(H2O)}2]4+ showed each yttrium atom to be coordinated to six nitrogens in the macrocycle, two hydroxide bridging units and one water molecule; the two macrocycles within the dimer have virtually identical conformations. Both dimeric complexes have the remarkable ability to degrade dsDNA, while the corresponding monomers have no activity. Cleavage likely involves random attack at single strands, in which closed circular plasmid DNA is initially converted to a nicked DNA intermediate before final cleavage.

Graphical abstract: Dimeric yttrium(iii) and neodymium(iii) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA

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Article information

DOI
https://doi.org/10.1039/B102533N
Article type
Paper
Submitted
19 Mar 2001
Accepted
03 Sep 2001
First published
11 Oct 2001

J. Chem. Soc., Dalton Trans., 2001, 3169-3172

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Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA

S. W. A. Bligh, N. Choi, E. G. Evagorou, M. McPartlin and K. N. White, J. Chem. Soc., Dalton Trans., 2001, 3169 DOI: 10.1039/B102533N

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