Issue 7, 2001
From the journal:

Chemical Communications

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomerCoordinates and structure factors have been deposited in the Protein Data Bank (pdb code 1i5w).

Martin Egli,*a   George Minasov,b   Marianna Teplova,a   Ravindra Kumarc  and  Jesper Wengelc  

* Corresponding authors

a Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA
E-mail: martin.egli@vanderbilt.edu

b Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois, USA

c Department of Chemistry, University of Southern Denmark, Odense M, Denmark

Abstract

Locked nucleic acid (LNA), a recently introduced nucleic acid analogue with a bicyclic 2′-O,4′-C-methylene linked furanose sugar, exhibits enhanced affinities for DNA and RNA relative to the corresponding oligodeoxyribonucleotides and oligoribonucleotides; we report the first crystal structure of an LNA unit incorporated in an oligonucleotide duplex. The structure at 1.4 Å resolution of the DNA–LNA decamer duplex with one LNA thymine monomer per strand provides a detailed view of the conformation and hydration of locked nucleic acid residues in a duplex A-form.

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Article information

DOI
https://doi.org/10.1039/B009447L
Article type
Communication
Submitted
27 Nov 2000
Accepted
22 Feb 2001
First published
14 Mar 2001

Chem. Commun., 2001, 651-652

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X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

M. Egli, G. Minasov, M. Teplova, R. Kumar and J. Wengel, Chem. Commun., 2001, 651 DOI: 10.1039/B009447L

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