Issue 23, 1993
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Chemo-enzymic synthesis of guanosine 5′-diphosphomannose (GDP-mannose) and selected analogues

Jane E. Pallanca  and  Nicholas J. Turner  

Abstract

Guanosine 5′-diphosphomannose (GDP-mannose, 1) has been prepared via two routes from α-D-mannose 1-phosphate 5. The non-enzymic route involves coupling of the phosphate 5 to guanosine 5′-monophosphate dibutyl phosphinothioc anhydride (GMP-anhydride 11) to give compound 1 in 40% yield. The enzymic routes require coupling of compound 5 with guanosine 5′-triphosphate (GTP) catalysed by GDP-mannose pyrophosphorylase (37% yield).

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Article information

DOI
https://doi.org/10.1039/P19930003017
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1993, 3017-3022

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Chemo-enzymic synthesis of guanosine 5′-diphosphomannose (GDP-mannose) and selected analogues

J. E. Pallanca and N. J. Turner, J. Chem. Soc., Perkin Trans. 1, 1993, 3017 DOI: 10.1039/P19930003017

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