Issue 7, 2023
From the journal:

RSC Sustainability

Thermo-switchable hydrophobic deep eutectic solvent for CuAAC†‡

Florence Charnay Pouget,a   Jean-Michel Andanson*a  and  Arnaud Gautier ORCID logo *a  

* Corresponding authors

a Université Clermont Auvergne, CNRS, ICCF, F-63000 Clermont–Ferrand, France
E-mail: J-Michel.Andanson@uca.fr, Arnaud.gautier@uca.fr

Abstract

The use of a deep eutectic solvent with thermo-switchable hydrophobicity properties (lidocaine: decanoic acid) is presented. Upon a gentle thermal trigger, the solvent separated into aqueous and organic layers. This system is well adapted for the CuAAC reaction using an N-heterocyclic carbene copper catalyst. An alkyne–azide cycloaddition of hydrophilic compounds, such as carbohydrates, could be conducted with good yields in the aqueous layer after the thermal separation. The method presented herein causes low contamination of the products by metals and the solvent can be reused at least five times.

Graphical abstract: Thermo-switchable hydrophobic deep eutectic solvent for CuAAC

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Article information

DOI
https://doi.org/10.1039/D3SU00249G
Article type
Paper
Submitted
19 Jul 2023
Accepted
28 Aug 2023
First published
11 Sep 2023
This article is Open Access
Creative Commons BY-NC license

RSC Sustain., 2023,1, 1826-1832

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Thermo-switchable hydrophobic deep eutectic solvent for CuAAC

F. C. Pouget, J. Andanson and A. Gautier, RSC Sustain., 2023, 1, 1826 DOI: 10.1039/D3SU00249G

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