Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers

Jessica Wagner; Marcel Dillenburger; Johanna Simon; Jennifer Oberländer; Katharina Landfester; Volker Mailänder; David Y. W. Ng; Klaus Müllen; Tanja Weil

doi:10.1039/D0CC02486D

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Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers†

Jessica Wagner,‡^ab Marcel Dillenburger,‡^a Johanna Simon,^ac Jennifer Oberländer,^ac Katharina Landfester,

^a Volker Mailänder,

^ac David Y. W. Ng,

^a Klaus Müllen

*^a and Tanja Weil

*^a

Author affiliations

* Corresponding authors

^a Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
E-mail: muellen@mpip-mainz.mpg.de, weil@mpip-mainz.mpg.de

^b Graduate School Materials Science in Mainz, Staudingerweg 9, 55128 Mainz, Germany

^c Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany

Abstract

Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.

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DOI: https://doi.org/10.1039/D0CC02486D
Article type: Communication
Submitted: 06 Apr 2020
Accepted: 15 Jun 2020
First published: 19 Jun 2020
This article is Open Access

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Chem. Commun., 2020,56, 8663-8666

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Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers

J. Wagner, M. Dillenburger, J. Simon, J. Oberländer, K. Landfester, V. Mailänder, D. Y. W. Ng, K. Müllen and T. Weil, Chem. Commun., 2020, 56, 8663 DOI: 10.1039/D0CC02486D

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Chemical Communications

Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers†

Abstract

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Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers

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