SCHEDULED MAINTENANCE
Spectroscopic and computational insights into the ion–solvent interactions in hydrated aprotic and protic ionic liquids†
Abstract
Ionic liquids (ILs) and their aqueous solutions are emerging media for solving and manipulating biochemical molecules such as proteins. Unleashing the full potential however requires a detailed mechanistic understanding of how suitable protic and aprotic ILs behave in the presence of water in the first place. The present work aims at making an important step by performing a combined experimental and computational study of two selected ILs and their mixtures with water: the aprotic cholinium propionate ([Chl][Pro]) and the protic N-methyl-2-pyrrolidonium propionate ([NMP][Pro]). IR and Raman spectroscopy reveal stronger ion–solvent interactions in [Chl][Pro]–H2O systems compared to [NMP][Pro]–H2O mixtures. This can be explained by the tightly packed ion-pair associations in [NMP][Pro] comprising the protic –N+–H counterpart, which allows the establishment of highly directional and strong interionic hydrogen bonds. The spectral decomposition of the O–D stretching band into three sub-peaks showed that the protic [NMP][Pro] favors the self-association of water molecules. On the other hand, the predominant fraction of water–anion/cation aggregates exists in aprotic [Chl][Pro]. These hydrated systems can be envisaged using quantum-chemical calculations in the following way: H2O⋯[Chl]+⋯H2O⋯[Pro]−⋯H2O and H2O⋯[NMP]+[Pro]−⋯H2O, which implied preferable solvent-shared ion-pair (SIP) configurations for [Chl][Pro]–H2O systems, whereas the contact ion-pair (CIP) state prevails for the [NMP][Pro]–H2O systems. The latter holds even in the water-rich regime. In future work, these findings will be the basis for an understanding of the underlying principles that govern the interactions of ions with bio-molecules in aqueous solutions.
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