Issue 68, 2018
From the journal:

RSC Advances

Multicomponent synthesis of pyrano[2,3-c]coumarins†

Wan-Chi Hsieh,a   Chi-Hui Lin,a   Yu-Ju Yanga  and  Ding-Yah Yang ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan
E-mail: yang@thu.edu.tw
Fax: 886-4-2359-0426
Tel: +886-4-2359-7613

Abstract

A base-catalyzed, pseudo-four-component reaction of 4-hydroxycoumarin, two molecules of acetone, and amine towards the synthesis of pyrano[2,3-c]coumarins is reported. The mechanism of this multicomponent reaction is proposed. The reaction is further extended to the preparation of coumarin-substituted pyrano[2,3-c]coumarins by a base-catalyzed, pseudo four-component reaction of two molecules of 4-hydroxycoumarin and two molecules of acetone.

Graphical abstract: Multicomponent synthesis of pyrano[2,3-c]coumarins

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Article information

DOI
https://doi.org/10.1039/C8RA06666C
Article type
Paper
Submitted
08 Aug 2018
Accepted
16 Nov 2018
First published
22 Nov 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 39162-39169

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Multicomponent synthesis of pyrano[2,3-c]coumarins

W. Hsieh, C. Lin, Y. Yang and D. Yang, RSC Adv., 2018, 8, 39162 DOI: 10.1039/C8RA06666C

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