Issue 14, 2018
From the journal:

Nanoscale

Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells†

Juan L. Paris,ab   Miguel Manzano, ORCID logo ab   M. Victoria Cabañas ORCID logo a  and  María Vallet-Regí ORCID logo *ab  

* Corresponding authors

a Dpto. Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, 28040-Madrid, Spain
E-mail: vallet@ucm.es

b Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

Abstract

A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is presented here. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively charged surface. This favors the internalization in human osteosarcoma cells, where the release of topotecan takes place, drastically enhancing the cytotoxic effect.

Graphical abstract: Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

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Article information

DOI
https://doi.org/10.1039/C8NR00693H
Article type
Paper
Submitted
24 Jan 2018
Accepted
26 Feb 2018
First published
27 Feb 2018

Nanoscale, 2018,10, 6402-6408

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Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

J. L. Paris, M. Manzano, M. V. Cabañas and M. Vallet-Regí, Nanoscale, 2018, 10, 6402 DOI: 10.1039/C8NR00693H

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