Issue 35, 2018

Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives

Abstract

A post-functionalization route to tris(dipyrrinato) metal complexes is presented giving access to a range of new complexes relevant in the context of medicinal inorganic chemistry. A pentafluorophenyl group in the meso-position of the dipyrrin ligand serves as an anchor for the connection with alcohols and thiocarbohydrates. The photochemotherapeutic activity of the complexes has been assessed in cellular assays with tumor cell lines and against the Gram-positive bacterium S. aureus. Finally, it is shown that this post-functionalization is also applicable to other dipyrrinato metal complexes.

Graphical abstract: Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives

Supplementary files

Article information

Article type
Paper
Submitted
26 Jul 2018
Accepted
08 Aug 2018
First published
08 Aug 2018

Dalton Trans., 2018,47, 12373-12384

Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives

C. S. Gutsche, S. Gräfe, B. Gitter, K. J. Flanagan, M. O. Senge, N. Kulak and A. Wiehe, Dalton Trans., 2018, 47, 12373 DOI: 10.1039/C8DT03059F

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