One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones†
Abstract
A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2,3-c]coumarins via a cascade reaction from chromones has been developed. This cascade reaction involves a Michael addition–Knoevenagel condensation–intramolecular cyclization. This transformation proceeds under mild conditions and gives various thieno[2,3-c]coumarins in good-to-excellent yields. The methodology is tolerant of a wide range of functional groups and applicable to library synthesis.
![Graphical abstract: One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6RA21776A&imageInfo.ImageIdentifier.Year=2016)
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