Lecanicillones A–C, three dimeric isomers of spiciferone A with a cyclobutane ring from an entomopathogenic fungus Lecanicillium sp. PR-M-3

Zai-Ying Wang; Xia-Nan Sang; Ke Sun; Sheng-Dong Huang; Sheng-Shuang Chen; Chun-Mei Xue; Lan-Feng Ban; Zhan-Lin Li; Hui-Ming Hua; Yue-Hu Pei; Jiao Bai

doi:10.1039/C6RA11422A

Lecanicillones A–C, three dimeric isomers of spiciferone A with a cyclobutane ring from an entomopathogenic fungus Lecanicillium sp. PR-M-3†

Zai-Ying Wang,^a Xia-Nan Sang,^a Ke Sun,^b Sheng-Dong Huang,^a Sheng-Shuang Chen,^a Chun-Mei Xue,^a Lan-Feng Ban,^b Zhan-Lin Li,^a Hui-Ming Hua,^a Yue-Hu Pei^a and Jiao Bai*^a

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* Corresponding authors

^a Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China

^b State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co., Ltd, Shenyang 110021, Liaoning, P. R. China

Abstract

Lecanicillones A–C (1–3), three unusual dimeric spiciferones with acyclobutane ring via a [2 + 2] cycloaddition, were isolated from an entomopathogenic fungus Lecanicillium sp. PR-M-3. The structures of 1–3 were elucidated on the basis of spectral data, single-crystal X-ray diffraction, and ECD analysis. Compounds 1 and 3 showed moderate cytotoxicity against the HL-60 cell line.

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Lecanicillones A–C, three dimeric isomers of spiciferone A with a cyclobutane ring from an entomopathogenic fungus Lecanicillium sp. PR-M-3†

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Lecanicillones A–C, three dimeric isomers of spiciferone A with a cyclobutane ring from an entomopathogenic fungus Lecanicillium sp. PR-M-3

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