Issue 63, 2016
From the journal:

RSC Advances

Base free regioselective synthesis of α-triazolylazine derivatives†

Mysore Bhyrappa Harisha,ab   Muthupandi Nagaraj,a   Shanmugam Muthusubramanian*a  and  Nattamai Bhuvaneshc  

* Corresponding authors

a Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai – 625 021, Tamil Nadu, India
E-mail: muthumanian2001@yahoo.com

b Advinus Therapeutics Limited, A TATA Enterprise, Bangalore – 560 058, India

c X-ray Diffraction Laboratory, Department of Chemistry, Texas A & M University, College Station, TX 77842, USA

Abstract

A regioselective α-heteroarylation followed by deoxygenation towards the synthesis of variety of azine triazole from simple azine N-oxides derivatives and N-tosyl-1,2,3-triazoles has been described. The reaction is metal free and base free with shorter reaction time, high yields and a broad substrate scope.

Graphical abstract: Base free regioselective synthesis of α-triazolylazine derivatives

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Article information

DOI
https://doi.org/10.1039/C6RA10452E
Article type
Paper
Submitted
22 Apr 2016
Accepted
07 Jun 2016
First published
13 Jun 2016

RSC Adv., 2016,6, 58118-58124

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Base free regioselective synthesis of α-triazolylazine derivatives

M. B. Harisha, M. Nagaraj, S. Muthusubramanian and N. Bhuvanesh, RSC Adv., 2016, 6, 58118 DOI: 10.1039/C6RA10452E

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