Issue 98, 2016

Molecular tweezers target a protein–protein interface and thereby modulate complex formation

Abstract

Molecular tweezers for lysine and arginine select a few residues on a protein surface and by their unique complexation mode disrupt a critical protein–protein interaction. Detailed structural information was gained by NMR experiments, strongly supported by QM/MM calculations and further substantiated by ITC, fluorescence anisotropy, ELISA and bio-layer-interference studies.

Graphical abstract: Molecular tweezers target a protein–protein interface and thereby modulate complex formation

Supplementary files

Article information

Article type
Communication
Submitted
05 Oct 2016
Accepted
14 Nov 2016
First published
15 Nov 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 14141-14144

Molecular tweezers target a protein–protein interface and thereby modulate complex formation

F. Trusch, K. Kowski, K. Bravo-Rodriguez, C. Beuck, A. Sowislok, B. Wettig, A. Matena, E. Sanchez-Garcia, H. Meyer, T. Schrader and P. Bayer, Chem. Commun., 2016, 52, 14141 DOI: 10.1039/C6CC08039A

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