Issue 8, 2016

Base-mediated isocyanide-based three-component reactions: divergent synthesis of spiro-substituted furans and pyrroles

Abstract

A facile base-mediated isocyanide-based three-component cycloaddition protocol for chemoselective formation of functionalized spiro-substituted furans and pyrroles derivatives has been developed. Fairly good yields of the products, the ready availability of the starting materials and the excellent chemoselectivity are the main advantages of this method.

Graphical abstract: Base-mediated isocyanide-based three-component reactions: divergent synthesis of spiro-substituted furans and pyrroles

Supplementary files

Article information

Article type
Paper
Submitted
30 Nov 2015
Accepted
06 Jan 2016
First published
11 Jan 2016

RSC Adv., 2016,6, 6459-6466

Author version available

Base-mediated isocyanide-based three-component reactions: divergent synthesis of spiro-substituted furans and pyrroles

H. Wang, M. Bao, B. Jiang and L. Li, RSC Adv., 2016, 6, 6459 DOI: 10.1039/C5RA25408F

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