Issue 52, 2015

Synthesis of a tetrasaccharide and its glycoconjugate corresponding to the capsular polysaccharide of Neisseria meningitidis serogroup X and its immunochemical studies

Abstract

A tetrameric unit of the capsular polysaccharide of Neisseria meningitidis X (MenX) consisting of α-linked 2-acetamido-2-deoxy-D-glucosyl phosphate moieties has been prepared with excellent yield using a sequential stereoselective coupling strategy and conjugated with the tetanus toxoid protein to furnish the glycoconjugate derivative. Good yields were achieved in all intermediate steps. The immunochemical properties of the tetrasaccharide and semi-synthetic glycoconjugate derivative have been evaluated for the development of a potential MenX vaccine candidate.

Graphical abstract: Synthesis of a tetrasaccharide and its glycoconjugate corresponding to the capsular polysaccharide of Neisseria meningitidis serogroup X and its immunochemical studies

Supplementary files

Article information

Article type
Paper
Submitted
16 Feb 2015
Accepted
29 Apr 2015
First published
29 Apr 2015

RSC Adv., 2015,5, 41332-41340

Synthesis of a tetrasaccharide and its glycoconjugate corresponding to the capsular polysaccharide of Neisseria meningitidis serogroup X and its immunochemical studies

K. R. Harale, N. B. Dumare, D. Singh, A. K. Misra and M. K. Chhikara, RSC Adv., 2015, 5, 41332 DOI: 10.1039/C5RA02993G

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