Issue 11, 2016

Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase

Abstract

A highly enantioselective Mannich reaction between 3-substituted-2H-1,4-benzoxazines and acetone catalyzed by lipase from wheat germ type I (WGL) is described. Enantioselectivity of up to 95% ee was achieved in DMSO at 25 °C. This research provides a new and simple method for the synthesis of β-amino ketone derivatives and promotes the development of enzyme-catalyzed Mannich reactions.

Graphical abstract: Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase

Supplementary files

Article information

Article type
Paper
Submitted
10 Nov 2015
Accepted
05 Jan 2016
First published
05 Jan 2016

Catal. Sci. Technol., 2016,6, 3963-3970

Author version available

Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase

L. Wu, Y. Xiang, D. Yang, Z. Guan and Y. He, Catal. Sci. Technol., 2016, 6, 3963 DOI: 10.1039/C5CY01923K

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