Issue 4, 2015
From the journal:

Chemical Communications

3-Pyrrolyl-oxindoles as efficient nucleophiles for organocatalytic asymmetric synthesis of structurally diverse 3,3′-disubstituted oxindole derivatives†

Bao-Dong Cui,‡ac   Yong You,‡ac   Jian-Qiang Zhao,ac   Jian Zuo,ac   Zhi-Jun Wu,b   Xiao-Ying Xu,a   Xiao-Mei Zhanga  and  Wei-Cheng Yuan*a  

* Corresponding authors

a National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
E-mail: yuanwc@cioc.ac.cn

b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China

c University of Chinese Academy of Sciences, Beijing 10049, China

Abstract

A range of 3-pyrrolyl-3,3′-disubstituted oxindoles were smoothly obtained via the reaction of 3-pyrrolyl-oxindoles with nitroalkenes using an organocatalyst. The usefulness of the protocol was also demonstrated by the versatile conversions of the Michael adducts into other functionalized 3,3′-disubstituted oxindoles, as well as into the analogues of some valuable natural products.

Graphical abstract: 3-Pyrrolyl-oxindoles as efficient nucleophiles for organocatalytic asymmetric synthesis of structurally diverse 3,3′-disubstituted oxindole derivatives

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC08364D
Article type
Communication
Submitted
23 Oct 2014
Accepted
18 Nov 2014
First published
19 Nov 2014

Chem. Commun., 2015,51, 757-760

Author version available

Download author version (PDF)

Permissions

Request permissions

3-Pyrrolyl-oxindoles as efficient nucleophiles for organocatalytic asymmetric synthesis of structurally diverse 3,3′-disubstituted oxindole derivatives

B. Cui, Y. You, J. Zhao, J. Zuo, Z. Wu, X. Xu, X. Zhang and W. Yuan, Chem. Commun., 2015, 51, 757 DOI: 10.1039/C4CC08364D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements