Selective synthesis of polyfunctionalized hydroisoquinoline derivatives via a three-component domino reaction†
Abstract
Two series of novel polyfunctionalized hydroisoquinoline derivatives have been synthesized via a three-component domino reaction of glutaraldehyde, malononitrile and 1,3-dicarbonyl compounds under microwave irradiation conditions in the presence of a catalytic amount of NaOH (10 mol%). Notably, this one-pot transformation allowed for the formation of six or seven new bonds and three new rings depending on the 1,3-dicarbonyl compound. Furthermore, this new multicomponent reaction proceeded rapidly, with the reaction reaching completion within 10 min.
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