Issue 67, 2013
From the journal:

Chemical Communications

Direct N-cyclopropylation of secondary acyclic amides promoted by copper†

Emilie Racine,a   Florian Monnier,*a   Jean-Pierre Vorsb  and  Marc Taillefer*a  

* Corresponding authors

a CNRS, UMR 5253, Institut Charles Gerhardt Montpellier AM2N, ENSCM, 8, rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France
E-mail: florian.monnier@enscm.fr, marc.taillefer@enscm.fr

b Bayer S.A.S., 14 Impasse Pierre Baizet, BP99163, 69263 Lyon CEDEX09, France

Abstract

The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.

Graphical abstract: Direct N-cyclopropylation of secondary acyclic amides promoted by copper

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Article information

DOI
https://doi.org/10.1039/C3CC42575D
Article type
Communication
Submitted
09 Apr 2013
Accepted
18 Jun 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 7412-7414

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Direct N-cyclopropylation of secondary acyclic amides promoted by copper

E. Racine, F. Monnier, J. Vors and M. Taillefer, Chem. Commun., 2013, 49, 7412 DOI: 10.1039/C3CC42575D

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