SCHEDULED MAINTENANCE
The structure–reactivity profile of tripeptides modified by methoxy substitution in the valinyl moiety of L-(α-aminoadipoyl)-L-cysteinyl-D-valine with the enzyme isopenicillin N synthase has been examined; substrate bulk and absolute configuration at the oxygen-substituted carbon were found to play crucial roles in determining substrate reactivity.
J. E. Baldwin, R. M. Adlington, A. Basak, P. Imming, K. Ponnamperuma, H. Ronneberg, C. J. Schofield, H. Ting and N. J. Turner, J. Chem. Soc., Chem. Commun., 1989, 802 DOI: 10.1039/C39890000802
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