Issue 6, 2013
From the journal:

RSC Advances

Synthesis and in vitro evaluation of antioxidant activity of diverse naphthopyranopyrimidines, diazaanthra[2,3-d][1,3]dioxole-7,9-dione and tetrahydrobenzo[a]xanthen-11-ones†

Jitender M. Khurana,*a   Anshika Lumb,a   Ankita Chaudharya  and  Bhaskara Nanda  

* Corresponding authors

a Department of Chemistry, University of Delhi, Delhi-110007, India
E-mail: jmkhurana1@yahoo.co.in
Fax: 91 11 27666605
Tel: 91 11 27667725

Abstract

A green and efficient one pot three component protocol has been developed for the synthesis of naphthopyranopyrimidines, diazaanthra[2,3-d][1,3]dioxole-7,9-dione and tetrahydrobenzo[a]xanthen-11-ones in PEG-400 catalyzed by alum (KAl(SO4)2·12H2O). Single crystal X-ray diffraction studies have been performed for naphthopyranopyrimidine (5). The synthesized compounds were screened for in vitro antioxidant activity by DPPH scavenging assay and compounds 3 and 4 manifested profound antioxidant potential.

Graphical abstract: Synthesis and in vitro evaluation of antioxidant activity of diverse naphthopyranopyrimidines, diazaanthra[2,3-d][1,3]dioxole-7,9-dione and tetrahydrobenzo[a]xanthen-11-ones

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Article information

DOI
https://doi.org/10.1039/C2RA22406B
Article type
Paper
Submitted
05 Oct 2012
Accepted
19 Nov 2012
First published
21 Nov 2012

RSC Adv., 2013,3, 1844-1854

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Synthesis and in vitro evaluation of antioxidant activity of diverse naphthopyranopyrimidines, diazaanthra[2,3-d][1,3]dioxole-7,9-dione and tetrahydrobenzo[a]xanthen-11-ones

J. M. Khurana, A. Lumb, A. Chaudhary and B. Nand, RSC Adv., 2013, 3, 1844 DOI: 10.1039/C2RA22406B

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