Issue 34, 2011
From the journal:

Chemical Communications

α-l-Arabinofuranosylated pyrrolidines as arabinanase inhibitors†‡

Ethan D. Goddard-Borger,§a   Raphael Carapito,b   Jean-Marc Jeltsch,b   Vincent Phalip,b   Robert V. Sticka  and  Annabelle Varrot*c  

* Corresponding authors

a School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Australia
E-mail: rvs@cyllene.uwa.edu.au

b Institut de recherche de l'Ecole de biotechnologie de Strasbourg, Boulevard Sébastien Brandt-BP 10413, 67412 ILLKIRCH Cedex, France
E-mail: phalip@unistra.fr
Fax: +33 368855330
Tel: +33 368854820

c CERMAV-CNRS, affiliated with Université Joseph Fourier and ICMG, BP 53, 38041 Grenoble cedex 9, France
E-mail: varrot@cermav.cnrs.fr
Fax: +33 476547203
Tel: +33 476037634

Abstract

As part of continued efforts to understand the mechanisms of 1,5-α-L-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant.

Graphical abstract: α-l-Arabinofuranosylated pyrrolidines as arabinanase inhibitors

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC13675E
Article type
Communication
Submitted
20 Jun 2011
Accepted
05 Jul 2011
First published
20 Jul 2011

Chem. Commun., 2011,47, 9684-9686

Permissions

Request permissions

α-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors

E. D. Goddard-Borger, R. Carapito, J. Jeltsch, V. Phalip, R. V. Stick and A. Varrot, Chem. Commun., 2011, 47, 9684 DOI: 10.1039/C1CC13675E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements