Issue 4, 2011
From the journal:

Polymer Chemistry

Self-immolative linkers in polymeric delivery systems

Christopher A. Blencowe,a   Andrew T. Russell,*a   Francesca Greco,b   Wayne Hayes*a  and  David W. Thornthwaitec  

* Corresponding authors

a Department of Chemistry, University of Reading, Whiteknights, Reading, United Kingdom
E-mail: a.t.russell@reading.ac.uk, w.c.hayes@reading.ac.uk
Fax: +44 118 378 6331
Tel: +44 118 378 6234

b Reading School of Pharmacy, University of Reading, Whiteknights, Reading, United Kingdom
E-mail: f.greco@reading.ac.uk
Fax: +44 118 378 4703
Tel: +0118 378 8244

c Unilever Research and Development, Quarry Road East, Bebington, Wirral, United Kingdom

Abstract

There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer. This ability has prompted numerous studies into the design and development of self-immolative linkers and the kinetics surrounding their disassembly. This review details the main concepts that underpin self-immolative linker technologies that feature in polymeric or dendritic conjugate systems and outlines the chemistries of amplified self-immolative elimination.

Graphical abstract: Self-immolative linkers in polymeric delivery systems

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Article information

DOI
https://doi.org/10.1039/C0PY00324G
Article type
Review Article
Submitted
28 Sep 2010
Accepted
30 Oct 2010
First published
18 Nov 2010

Polym. Chem., 2011,2, 773-790

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Self-immolative linkers in polymeric delivery systems

C. A. Blencowe, A. T. Russell, F. Greco, W. Hayes and D. W. Thornthwaite, Polym. Chem., 2011, 2, 773 DOI: 10.1039/C0PY00324G

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