Issue 7, 2011
From the journal:

Organic & Biomolecular Chemistry

Aggregation behaviour of peptide–polymer conjugates containing linear peptide backbones and multiple polymer side chains prepared by nitroxide-mediated radical polymerization†‡

Michael Möller,a   Carsten Hentschel,b   Lifeng Chib  and  Armido Studer*a  

* Corresponding authors

a Organisch-Chemisches Institut and NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, Münster, Germany
E-mail: studer@uni-muenster.de
Fax: +49-251-833-6523
Tel: +49-251-833-3291

b Physikalisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Straße 10, Münster, Germany
E-mail: chi@uni-muenster.de
Fax: +49-251-833-3602
Tel: +49-251-833-3651

Abstract

A series of peptides with an alternating sequence of alkoxyamine conjugated lysine and glycine residues were synthesized by classical solution phase peptide coupling. The resulting peptides containing up to eight alkoxyamine moieties were used as initiators in nitroxide-mediated polymerization (NMP) to obtain peptide–polymer conjugates with well defined linear peptide backbones and a defined number of polymeric side chains. Polymerization of styrene and N-isopropylacrylamide (NIPAM) occurred in a highly controlled fashion. Molecular weight and polydispersity index (PDI) were determined by gel permeation chromatography (GPC). Aggregation behaviour of these hybrid materials was investigated by dynamic light scattering (DLS) and atomic force microscopy (AFM). Depending on composition, number and length of the polymer side chains, the conjugates aggregate to different topologies. Whereas peptide–polystyrene conjugates may aggregate to so called honeycomb structures, peptide–poly-N-isopropylacrylamide conjugates show differentiated aggregation behaviour.

Graphical abstract: Aggregation behaviour of peptide–polymer conjugates containing linear peptide backbones and multiple polymer side chains prepared by nitroxide-mediated radical polymerization

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Article information

DOI
https://doi.org/10.1039/C0OB01047B
Article type
Paper
Submitted
18 Nov 2010
Accepted
07 Jan 2011
First published
14 Feb 2011

Org. Biomol. Chem., 2011,9, 2403-2412

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Aggregation behaviour of peptide–polymer conjugates containing linear peptide backbones and multiple polymer side chains prepared by nitroxide-mediated radical polymerization

M. Möller, C. Hentschel, L. Chi and A. Studer, Org. Biomol. Chem., 2011, 9, 2403 DOI: 10.1039/C0OB01047B

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