Issue 1, 2008
From the journal:

Soft Matter

Flexible macromolecules attached to lipid bilayers: impact on fluidity, curvature, permeability and stability of the membranes

Christophe Tribeta  and  Florent Viala  

a Physico-chimie des Polymères et Milieux Dispersés, CNRS UMR 7615 and Université Paris 6, ESPCI, 10 rue Vauquelin, F-75005 Paris, France

Abstract

This review summarizes recent investigations on the association of macromolecules on lipid bilayers. Hydrophilic and flexible polymers can form soft coronae tenuously adsorbed or anchored on the lipid membrane. Other synthetic macromolecules are embedded in the apolar region of the membrane. Recent experimental and theoretical works focus on the perturbation of lipid properties achieved depending on the nature and strength of binding. Of importance to biomimicry, to tethered model membranes, and drug carriers, the effects achievable include modulation of the lateral diffusivity of lipids, shape distortions, lateral segregations, formation of well-defined nanopores and ultimately the stimuli responsive disruption of the membrane.

Graphical abstract: Flexible macromolecules attached to lipid bilayers: impact on fluidity, curvature, permeability and stability of the membranes

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Article information

DOI
https://doi.org/10.1039/B708431P
Article type
Review Article
Submitted
04 Jun 2007
Accepted
19 Sep 2007
First published
11 Oct 2007

Soft Matter, 2008,4, 68-81

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Flexible macromolecules attached to lipid bilayers: impact on fluidity, curvature, permeability and stability of the membranes

C. Tribet and F. Vial, Soft Matter, 2008, 4, 68 DOI: 10.1039/B708431P

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