Issue 16, 2004
From the journal:

Organic & Biomolecular Chemistry

Silenes as novel synthetic reagents: identification of a practical method for silene generation and trapping

Malcolm B. Berry,b   Russell J. Griffiths,a   Mahesh J. Sanganee,b   Patrick G. Steel*a  and  Daniel K. Whelligana  

* Corresponding authors

a Department of Chemistry, University of Durham, Science Laboratories, South Road, Durham, UK
E-mail: p.g.steel@durham.ac.uk

b Synthetic Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts., UK

Abstract

The elucidation of a robust and reliable sequence for the generation of highly reactive transient silenes from simple aldehydes is described. The key step involves a silyl-modified Peterson olefination which critically depends on the presence of a sub-stoichiometric amount of soluble lithium salts (LiBr).

Graphical abstract: Silenes as novel synthetic reagents: identification of a practical method for silene generation and trapping

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B404166F
Article type
Paper
Submitted
22 Mar 2004
Accepted
22 Jun 2004
First published
28 Jul 2004

Org. Biomol. Chem., 2004,2, 2381-2392

Permissions

Request permissions

Silenes as novel synthetic reagents: identification of a practical method for silene generation and trapping

M. B. Berry, R. J. Griffiths, M. J. Sanganee, P. G. Steel and D. K. Whelligan, Org. Biomol. Chem., 2004, 2, 2381 DOI: 10.1039/B404166F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements