Issue 43, 2013
From the journal:

RSC Advances

Iodine-catalyzed three component reaction: a novel synthesis of 2-aryl-imidazo[1,2-a]pyridine scaffolds†

Kallimeledoddi Boregowda Puttarajua  and  Kalegowda Shivashankar*a  

* Corresponding authors

a P.G. Department of Chemistry, Central College Campus, Bangalore University, Bangalore-560 001, Karnataka, India
E-mail: shivashankark@gmail.com
Tel: +91 80 22961249

Abstract

A facile and efficient protocol for the synthesis of novel 2-aryl-imidazo[1,2-a]pyridines has been developed via a one-pot reaction of aromatic aldehydes with 2-amino-5-chloropyridine and tert-butylisocyanide in the presence of I2 in ethanol at 70 °C. The present approach offers the advantages of a clean and simple methodology, high atom-economy, mild conditions, short reaction times, wide substrate scope, low environmental impact and high yield.

Graphical abstract: Iodine-catalyzed three component reaction: a novel synthesis of 2-aryl-imidazo[1,2-a]pyridine scaffolds

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Article information

DOI
https://doi.org/10.1039/C3RA43407A
Article type
Paper
Submitted
05 Jul 2013
Accepted
14 Aug 2013
First published
15 Aug 2013

RSC Adv., 2013,3, 20883-20890

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Iodine-catalyzed three component reaction: a novel synthesis of 2-aryl-imidazo[1,2-a]pyridine scaffolds

K. B. Puttaraju and K. Shivashankar, RSC Adv., 2013, 3, 20883 DOI: 10.1039/C3RA43407A

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