Issue 4, 2008
From the journal:

Natural Product Reports

Metabolic engineering of microorganisms for isoprenoid production

James Kirbyb  and  Jay D. Keasling*abcde  

* Corresponding authors

a Berkeley Center for Synthetic Biology, 717 Potter Street, Building 977, Mail code 3224, University of California, Berkeley, CA, USA
E-mail: keasling@berkeley.edu
Fax: +1 (510) 495-2630
Tel: +1 (510) 495-2620

b California Institute of Quantitative Biomedical Research, University of California, Berkeley, CA, USA

c Department of Chemical Engineering, University of California, Berkeley, CA, USA

d Department of Bioengineering, University of California, Berkeley, CA, USA

e Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

Abstract

Covering: up to the end of 2007

Isoprenoids are ubiquitous in nature and range from essential cell components to unique secondary metabolites. The two isoprenoid biosynthetic pathways have received much attention from a metabolic engineering standpoint, and significant advances have been made in increasing flux through these pathways. Engineering later steps in isoprenoid biosynthetic pathways, specifically those related to the functionalization of terpene backbones, is at an earlier stage of development, both in terms of gene discovery and heterologous expression. Here we review recent advances in the metabolic engineering of microbes for isoprenoid production as well as some novel approaches to gene discovery and expression.

Graphical abstract: Metabolic engineering of microorganisms for isoprenoid production

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Article information

DOI
https://doi.org/10.1039/B802939C
Article type
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Submitted
20 Feb 2008
First published
25 Apr 2008

Nat. Prod. Rep., 2008,25, 656-661

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Metabolic engineering of microorganisms for isoprenoid production

J. Kirby and J. D. Keasling, Nat. Prod. Rep., 2008, 25, 656 DOI: 10.1039/B802939C

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