Fluorinase mediated C–18F bond formation, an enzymatic tool for PET labelling

Hai Deng; Steven L. Cobb; Antony D. Gee; Andrew Lockhart; Laurent Martarello; Ryan P. McGlinchey; David O'Hagan; Mayca Onega

doi:10.1039/B516861A

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Fluorinase mediated C–¹⁸F bond formation, an enzymatic tool for PET labelling†

Hai Deng,^a Steven L. Cobb,^a Antony D. Gee,^b Andrew Lockhart,^b Laurent Martarello,‡*^b Ryan P. McGlinchey,^a David O'Hagan*^a and Mayca Onega^a

Author affiliations

* Corresponding authors

^a University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UK
E-mail: do1@st-andrews.ac.uk
Fax: 01334 463800
Tel: 01334 467171

^b GlaxoSmithKline, Addenbrooke's Hospital, Hills Road, Cambridge, UK
E-mail: Antony_D_Gee@gsk.com
Fax: 01223 296063
Tel: 01223 296120

Abstract

The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [¹⁸F]-fluoride into [¹⁸F]-5′-fluoro-5′-deoxyadenosine, [¹⁸F]-5′-fluoro-5′-deoxyinosine and [¹⁸F]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

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Supplementary files

Experimental section PDF (155K)

Article information

DOI: https://doi.org/10.1039/B516861A
Article type: Communication
Submitted: 28 Nov 2005
Accepted: 10 Jan 2006
First published: 18 Jan 2006

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Chem. Commun., 2006, 652-654

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Fluorinase mediated C–¹⁸F bond formation, an enzymatic tool for PET labelling

H. Deng, S. L. Cobb, A. D. Gee, A. Lockhart, L. Martarello, R. P. McGlinchey, D. O'Hagan and M. Onega, Chem. Commun., 2006, 652 DOI: 10.1039/B516861A

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