Issue 54, 2021

Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

Abstract

Sterically shielded 1,2,4-trioxolanes prepared by Griesbaum co-ozonolysis have been utilized as chemical sensors of ferrous iron in several recently described chemical probes of labile iron. Here we report optimized conditions for co-ozonolysis that proceed efficiently and with high diastereoselectivity across an expanded range of substrates, and should enable a new generation of labile iron probes with altered reaction kinetics and physicochemical properties.

Graphical abstract: Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
05 Aug 2021
Accepted
11 Oct 2021
First published
22 Oct 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 34338-34342

Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

J. Chen, R. L. Gonciarz and A. R. Renslo, RSC Adv., 2021, 11, 34338 DOI: 10.1039/D1RA05932G

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