Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis?

Abstract

Transmembrane proteases (TPs) are proteins anchored in the plasma membrane with their catalytic site exposed to the external surface of the membrane. TPs are widely expressed, and their dysregulated expression is associated with cancer, infection, inflammation, autoimmune and cardiovascular diseases, all diseases where angiogenesis is part of the pathology. TPs participate in extracellular proteolysis (degradation of extracellular matrix components, regulation of chemokine activity, release of membrane-anchored cytokines, cytokine receptors and adhesion molecules) and influence cell functions (growth, secretion of angiogenic molecules, motility). Recent attention has been focused on the ADAM-17 (a disintegrin and metalloprotease)/TACE/CD156q, the MT1-MMP (membrane-type-1 matrix metallo proteinase)/MMP-14, and the ectopeptidases aminopeptidase N (APN/CD13), dipeptidyl peptidase IV (DPPIV/CD26) and angiotensin-converting enzyme (ACE/CD143), that appear to have a critical role in angiogenesis. This article summarizes current knowledge on these TPs, and reviews recent investigations that document their participation during angiogenic-related events. Through their multiple roles, TPs may thereby provide critical links in angiogenesis.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  • Afzal S, Lalani EN, Poulsom R, Stubbs A, Rowlinson G, Sato H, Seiki M and Stamp GW . (1998). Hum. Pathol., 29, 155–165.

  • Ahmad S and Ward PE . (1990). J. Pharmacol. Exp. Ther., 252, 643–650.

  • Alhenc-Gelas F, Costerousse O and Danilov S . (1997). Cell-Surface Peptidases in Health and Disease, Kenny AJ and Boustead CM (eds). BIOS Scientific Publishers: Oxford, 119–135.

    Google Scholar 

  • Annabi B, Lachambre M, Bousquet-Gagnon N, Page M, Gingras D and Beliveau R . (2001). Biochem. J., 353, 547–553.

  • Antczak C, De Meester I and Bauvois B . (2001a). BioEssays, 23, 1–10.

  • Antczak C, De Meester I and Bauvois B . (2001b). J. Biol. Regul. Homeost. Agents, 15, 130–139.

  • Asher JR and Naftilan AJ . (2000). Curr. Hypertens. Rep., 2, 384–391.

  • Bannikov GA, Karelina TV, Collier IE, Marmer BL and Goldberg GI . (2002). J. Biol. Chem., 277, 16022–16027.

  • Bauvois B . (2001). J. Leukoc. Biol., 70, 11–17.

  • Beckner M . (1999). Cancer Invest., 17, 594–623.

  • Bermpohl F, Löster K, Reutter W and Baum O . (1998). FEES Lett., 428, 152–156.

  • Bernardini G, Ribatti D, Spinetti G, Morbidelli L, Ziche M, Santoni A, Capogrossi MC and Napolitano M . (2003). J. Immunol. Methods, 273, 83–101.

  • Bernstein KE . (1998). Am. J. Cardiol., 82, 5S–7S.

  • Bhagwat S, Lahdenranta J, Giordano R, Arap W, Pasqualini R and Shapiro LH . (2001). Blood, 97, 652–659.

  • Bischof P, Meisser A and Campana A . (2002). J. Reprod. Immunol., 55, 3–10.

  • Black RA . (2002). Int. J. Biochem. Cell. Biol., 34, 1–5.

  • Blood pressure lowering treatment trialists collaboration (2000). Lancet, 356, 1955–1964.

  • Brinckerhoff CE, Rutter JL and Benbow U . (2000). Clin. Cancer Res., 612, 4823–4830.

  • Bueno C, Rodriguez-Caballero A, Garcia-Montero A, Pandiella A, Almeida J and Orfao A . (2002). J. Immunol. Methods, 264, 77–87.

  • Burnett JC . (1999). J. Hypertens. Suppl., 17, 537–543.

  • Burrell LM, Droogh J, Manin't Veld O, Rockell MD, Farina NK and Johnston CL . (2000). Am. J. Hypertens., 13, 1110–1116.

  • Butler GS, Butler MJ, Atkinson SJ, Wills H, Tamura T, Schade van Westrum S, Crabbe T, Clements J, d'Ortho MP and Murphy G . (1998). J. Biol. Chem., 273, 871–880.

  • Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM, Bara L and Ricard S et al. (1992). Nature, 1359, 641–644.

  • Cambien F and Soubrier F . (1995). Hypertension: Pathophysiology, Diagnosis and Management, 2nd ed. Laragh JH and Brenner BM (eds). Raven Press Ltd: New York, 1667–1682.

    Google Scholar 

  • Cerretti DP . (1999). Biochem. Soc. Trans., 27, 219–223.

  • Chan VT, Zhang DN, Nagaravapu U, Hultquist K, Romero LI and Herron GS . (1998). J. Invest. Dermatol., 111, 1153–1159.

  • Chang C and Werb Z . (2001). Trends Cell. Biol., 11, 37–43.

  • Chen WT and Kelly T . (2003). Cancer Metast. Rev., 22, 259–269.

  • Chomarat P, Rissoan MC, Pin JJ, Banchereau J and Miossec P . (1995). J. Immunol., 155, 3645–3652.

  • Collen A, Hanemzzijer R, Lupu F, Quax PHA, van Lent N, Grimberg J, Peters E, Koolwijk P and van Hinsbergh VWM . (2003). Blood, 101, 1810–1817.

  • Colon A, Menchen LA, Hurtado O, De Cristobal J, Lizasoain I, Leza JC, Lorenzo P and Moro MA . (2001). Cytokine, 16, 220–226.

  • Comte L, Lorgeot V, Volkov L, Allegraud A, Aldigier JC and Praloran V . (1997). Eur. J. Clin. Invest., 27, 788–790.

  • Condon T, Flournoy S, Sawyer GJ, Baker BF, Kishimoto TK and Bennett CF . (2001). Antisense Nucleic Acid Drug Dev., 11, 107–116.

  • Constantinescu CS, Goodman DB and Ventura ES . (1998). Immunol. Lett., 62, 25–31.

  • Conway J, Andrews RC, Beaudet B, Bickett DM, Boncek V, Brodie TA, Clark RL, Crumrine RC, Leenitzer MA, McDougald DL, Han B, Hedeen K, Lin P, Milla M, Moss M, Pink H, Rabinowitz MH, Tippin T, Scates PW, Selph J, Stimpson SA, Warner J and Becherer JD . (2001). J. Pharmacol Exp. Ther., 298, 900–908.

  • Crowther M, Brown NJ, Bishop ET and Lewis CE . (2001). J. Leukoc. Biol., 70, 478–490.

  • Curran S and Murray GI . (1999). J. Pathol., 189, 300–308.

  • d'Ortho M, Stanton H, Butler M, Atkinson SJ, Murphy G and Hembry RM . (1998). FEBS Lett., 421, 159–164.

  • Danilov S, Savoie F, Lenoir B, Jeunemaitre X, Azizi M, Tarnow L and Alhenc-Gelas F . (1996). J. Hypertens., 14, 719–727.

  • De Meester I, Korom S, Van Damme J and Scharpé S . (1999). Immunol. Today, 20, 367–375.

  • Diaz-Flores L, Gutierrez R and Varela H . (1994). Histol. Histopathol., 9, 807–843.

  • Doggrell S . (2002). Expert Opin. Invest. Drugs, 11, 1003–1006.

  • Egeblad M and Werb Z . (2002). Nat. Rev., 2, 161–174.

  • Ellenrieder V, Alber B, Lacher U, Hendler SF, Menke A, Boek W, Wagner M, Wilda M, Friess H, Buchler M, Adler G and Gress TM . (2000). Int. J. Cancer, 1, 14–20.

  • Ellerbrock SM and Stack MS . (1999). BioEssays, 21, 940–949.

  • Ellis LM, Liu W, Ahmad SA, Fan F, Jung YD, Shaheen RM and Reinmuth N . (2001). Semin. Oncol., 28, 94–104.

  • Emanueli C, Salis MB, Stacca T, Pinna A, Gaspa L, Spano A and Madeddu P . (2002). Am. J. Hypertens., 15, 410–415.

  • Erbe DV, Watson SR, Presta LG, Wolitzky BA, Foxall C, Brandley BK and Lasky LA . (1993). J. Cell Biol., 120, 1227–1235.

  • Fabre JE, Rivard A, Magner M, Silver M and Isner J . (1999). Circulation, 99, 3043–3049.

  • Feinberg MW, Jain MK, Werner F, Sibinga NE, Wiesel P, Wang H, Topper JN, Perrella MA and Lee ME . (2000). J. Biol. Chem., 275, 25766–25773.

  • Fillmore HL, vanMeter TE and Broaddus WC . (2001). J. Neuro-oncol., 53, 187–202.

  • Flather MD, Yusuf S, Kober L, Pfeffer M, Hall A, Murray G, Torp-Pedersen C, Ball S, Pogue J, Moyé L and Braunwald E . (2000). Lancet, 355, 1575–1581.

  • Franzke CW, Tasanen K, Schacke H, Zhou Z, Tryggvason K, Mauch C, Zigrino P, Sunnarborg S, Lee DC, Fahrenholz F and Bruckner-Tuderman L . (2002). EMBO J., 21, 5026–5035.

  • Fujii H, Nakajima M, Saiki I, Yoneda J, Azuma I and Tsuruo T . (1995). Clin. Exp. Metast., 13, 337–344.

  • Glicklich D, Kapoian T, Gilman J, Tellis V and Croizat H . (1999). Transplantation, 68, 62–66.

  • Goding JW . (2000). J. Leukoc. Biol., 67, 285–311.

  • Gonzalez-Gronow M, Grenett HE, Weber MR, Gawdi G and Pizzo SV . (2001). Biochem. J., 355, 397–407.

  • Griffioen AW and Molema G . (2000). Pharmacol. Rev., 52, 237–268.

  • Hadjadj S, Belloum R, Bouhanick B, Gallois Y, Guilloteau G, Chatellier G, Alhenc-Gelas F and Marre M . (2001). J. Am. Soc. Nephrol., 12, 541–549.

  • Hagaman JR, Moyer JS, Bachman ES, Sibony M, Magyar PL, Welch JE, Smithies O, Krege JH and O'Brien DA . (1998). Proc. Natl. Acad. Sci. USA., 95, 2552–2557.

  • Hansen H, Dietrich S, Kisseleva T, Mokros T, Mentlein R, Lange HH, Murphy G and Lemke H . (2000). J. Immunol, 165, 6703–6709.

  • Harada T, Arii S, Mise M, Imamura T, Higashitsuji H, Furutani M, Niwano M, Ishigami S, Fukumoto M, Seiki M, Sato H and Imamura M . (1998). J. Hepatol., 28, 231–239.

  • Hashida H, Takabayashi A, Kanai M, Adachi M, Kondo K, Kohno N, Yamaoka Y and Miyake M . (2002). Gastroenterology, 122, 376–386.

  • Hernandez-Barrantes S, Toth M, Bernardo MM, Yurkova M, Gervasi DC, Raz Y, Sang QA and Fridman R . (2000). J. Biol. Chem., 275, 12080–12089.

  • Hiscox S and Jiang WG . (1997). In Vivo, 11, 125–132.

  • Höckel M, Schlenger K, Doctrow S, Kissel T and Vaupel P . (1993). Arch. Surg., 128, 423–429.

  • Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, Mankani M, Robey PG, Poole AR, Pidoux I, Ward JM and Birkedal-Hansen H . (1999). Cell, 99, 81–92.

  • Honda S, Migita K, Hirai Y, Origuchi T, Yamasaki S, Kamachi M, Shibatomi K, Fukuda T, Kita M, Hida A, Ida H, Aoyagi T, Kawakami A, Kawabe Y, Oizumi K and Eguchi K . (2001). Clin. Exp. Immunol., 126, 131–136.

  • Hooper NM and Turner AJ . (2002). Curr. Med. Chem., 9, 1107–1119.

  • Isacke CM and Yarwood H . (2002). Int. J. Biochem. Cell. Biol., 34, 718–721.

  • Ishigaki S, Toi M, Ueno T, Matsumoto H, Muta M, Koike M and Seiki M . (1999). Jpn J. Cancer Res., 90, 516–522.

  • Ishii N, Ogawa Z, Itoh H, Ikenaga H and Saruta T . (1994). Enzyme Protein, 48, 174–182.

  • Ishii K, Usui S, Sugimura Y, Yamamoto H, Yoshikawa K and Hirano K . (2001). Biol. Pharm. Bull., 24, 226–230.

  • Kajita M, Itoh Y, Chiba T, Mori H, Okada A, Kinoh H and Seiki M . (2001). J. Cell Biol., 153, 893–904.

  • Karkkainen I, Rybnikova E, Pelto-Huikko M and Huovila AP . (2000). Mol. Cell. Neurosci., 15, 547–560.

  • Kawai M, Otake Y and Hara Y . (2003). Clin. Chim. Acta, 330, 141–149.

  • Kerkela E, Ala-aho R, Lohi J, Grenman R, M-Kahari V and Saarialho-Kere U . (2001). Br. J. Cancer, 84, 659–669.

  • Kitagawa Y, Kunimi K, Ito H, Sato H, Uchibayashi T, Okada Y, Seiki M and Namiki M . (1998). J. Urol., 160, 1540–1545.

  • Knauper V, Will H, Lopez-Otin C, Smith B, Atkinson SJ, Stanton H, Hembry RM and Murphy G . (1996). J. Biol. Chem., 271, 17124–17131.

  • Knox AJ, Corbett L, Stocks J, Holland E, Zhu YM and Pang L . (2001). FASEB J., 15, 2480–2488.

  • Koike T, Vernon RB, Hamner MA, Sadoun E and Reeds MJ . (2002). J. Cell. Biochem., 86, 748–758.

  • Korom S, De Meester I, Coito AJ, Graser E, Pratschke J, König S, Grimm H, Volk HD and Scharpé S . (1999). Transplant. Proc., 31, 87.

  • Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA and Smithies O . (1995). Nature, 375, 146–148.

  • Kuro T, Okahara A, Nose M, Ikuse T and Matsumura Y . (2000). Biol. Pharm. Bull., 23, 820–825.

  • Kuroi K and Toï M . (2001). Int. J. Biol. Markers, 16, 5–26.

  • Lafleur MA, Handsley MM, Knaupper V, Murphy G and Edwards DR . (2002). J. Cell Sci., 115, 3427–3438.

  • Laurent S, Boutouyrie P, Azizi M, Marie C, Gros C, Schwartz JC, Lecomte JM and Bralet J . (2000). Hypertension, 35, 48–53.

  • Lever AF, Hole DJ, Gillis CR, McCallum IR, Mclnnes GT, MacKinnon PL, Meredith PA, Murray LS, Reid JL and Robertson JW . (1998). Lancet, 352, 179–184.

  • Li L, Eisen AZ, Sturman E and Seltzer JL . (1998). Biochim. Biophys. Acta, 1405, 110–120.

  • Lohn M, Mueller C and Langner J . (2002). Leuk. Lymphoma, 43, 407–413.

  • Lucas A, Dai E, Liu LY and Nation PN . (1998). Cardiovasc. Res., 38, 237–246.

  • Ludwig A, Schiemann F, Mentlein R, Lindner B and Brandt E . (2002). J. Leukoc. Biol., 72, 183–191.

  • Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ and Wagtmann N . (2000). Proc. Natl. Acad. Sci. USA, 97, 6874–6879.

  • Mattei MG, Roeckel N, Olsen BR and Apte SS . (1997). Genomics, 40, 168–169.

  • McCawley LJ and Matrisian LM . (2000). Mol. Med. Today, 6, 149–156.

  • McClean DR, Ikram H, Garlick AH and Crozier IG . (2001). Am. J. Cardiol., 87, 565–569.

  • Meisser A, Chardonnens D, Campana A and Bischof P . (1999). Mol. Hum. Reprod., 5, 252–260.

  • Mishima Y, Matsumoto-Mishima Y, Terui Y, Katsuyama M, Yamada M, Mori M, Ishizaka Y, Ikeda K, Watanabe J, Mizunuma N, Hayasawa H and Hatake K . (2002). J. Natl. Cancer Inst., 94, 1020–1028.

  • Moehler T, Neben K, Ho AD and Goldschmidt H . (2001). Ann. Hematol., 80, 695–705.

  • Moses MA . (1997). Stem Cells, 15, 180–189.

  • Moss ML and Lambert MH . (2002). Essays Biochem., 38, 141–153.

  • Murphy G and Gavrilovic J . (1999). Curr. Opin. Cell Biol., 11, 614–621.

  • Nagase H and Woessner Jr JF . (1999). J. Biol. Chem., 274, 21491–21494.

  • Napoleone E, Di Santo A, Camera M, Tremoli M and Lorenzet R . (2000). Circ. Res., 86, 139–143.

  • Neal B, MacMahon S and Chapman N . (2000). Lancet, 356, 1955–1964.

  • Newton R, Solomon KA, Covington MB, Decicco CP, Haley PJ, Friedman SM and Vaddi K . (2001). Ann. Rheum. Dis., 60, 25–32.

  • Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C and Noda M . (2001). Cell, 107, 789–800.

  • Ohta S, Harigai M, Tanaka M, Kawaguchi Y, Sugiura T, Takagi K, Fukasawa C, Hara M and Kamatani N . (2001). J. Rheumatol., 28, 1756–1763.

  • Ohuchi E, Imai K, Fujii Y, Sato H, Seiki M and Okada Y . (1997). J. Biol. Chem., 272, 2446–2451.

  • Opdenakker G and Van Damme J . (2002). Verh. K. cad. Geneeskd. Belg., 64, 105–136.

  • Pap T, Shigeyama Y, Kuchen S, Fernihough JK, Simmen B, Gay RE, Billingham M and Gay S . (2000). Arthritis Rheum., 43, 1226–1232.

  • Papies B, Frille J, Gunther KH and Wagenknecht C . (1991). Cor. Vasa., 33, 218–226.

  • Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W and Ruoslahti E . (2000). Cancer Res., 60, 722–727.

  • Patel I, Attur MG, Patel RN, Stuchin SA, Abagyan RA, Abramson SB and Amin AR . (1998). J. Immunol, 160, 4570–4579.

  • Phillips MI and Kagiyama S . (2002). Curr. Opin. Invest. Drugs, 3, 569–577.

  • Piepho RW . (2000). Am. J. Health Syst. Pharm., 57, 53–57.

  • Primakoff P and Myles DG . (2000). Trends Genet., 16, 83–87.

  • Proost P, Menten P, Struyf S, Schutyser E, De Meester I and Van Damme J . (2000). Blood, 96, 1674–1680.

  • Proost P, Schutyser E, Menten P, Struyf S, Wuyts A, Opdenakker G, Detheux M, Parmentier M, Durinx C, Lambeir AM, Neyts J, Liekens S, Maudgal PC, Billiau A and Van Damme J . (2001). Blood, 98, 3554–3561.

  • Prud'homme GJ and Piccirillo CA . (2000). J. Autoimmun., 14, 23–42.

  • Rajavashisth TB, Xu XP, Jovinge S, Meisel S, Xu XO, Chai NN, Fishbein MC, Kaul S, Cercek B, Sharifi B and Shah PK . (1999). Circulation, 99, 3103–3109.

  • Ribatti D, Vacca A, Roncali L and Dammacco F . (2000). J. Hematother. Stem Cell. Res., 9, 13–19.

  • Riemann D, Kehlen A and Langner J . (1999). Immunol. Today, 20, 83–88.

  • Rouleau JL, Pfeffer MA, Stewart DJ, Isaac D, Sestier F, Kerut EK, Porter CB, Proulx G, Qian C and Block AJ . (2000). Lancet, 356, 615–620.

  • Rovida E, Paccagnini A, Del Rosso M, Peschon J and Dello Sbarba P . (2001). J. Immunol., 166, 1583–1589.

  • Saiki I, Fujii H, Yoneda J, Abe F, Nakajima M, Tsuruo T and Azuma I . (1993). Int. J. Cancer, 54, 137–143.

  • Samani N, Thompson JR, O'Toole L, Channer K and Woods KL . (1996). Circulation, 94, 708–712.

  • Santos A, Langner J, Herrmann M and Riemann D . (2000). Thromb. Haemost., 78, 497–500.

  • Satoh M, Nakamura M, Satoh H, Saitoh H, Segawa I and Hiramori K . (2000). J. Am. Coll. Cardiol., 36, 1288–1294.

  • Scheel-Toellner D, Richter E, Toellner KM, Reiling N, Wacker HH, Flad HD and Gerdes J . (1995). Lab. Invest., 73, 685–690.

  • Schonermarck U, Csernok E, Trabandt A, Hansen H and Gross WL . (2000). Clin. Exp. Rheumatol., 18, 457–463.

  • Schwartz J, Shamamian P, Monea S, Whiting D, Marcus SG, Galloway AC and Mignatti P . (1998). Surgery, 124, 232–238.

  • Seifert T, Kieseier BC, Ropele S, Strasser-Fuchs S, Quehenberger F, Fazekas F and Hartung HP . (2002). Multiple Sclerosis., 8, 447–451.

  • Seiki M . (2002). Curr. Opin. Cell Boil., 14, 624–632.

  • Seiki M and Yana I . (2003). Cancer Sci., 94, 569–574.

  • Silvestre JS, Bergaya S, Tamarat R, Duriez M, Boulanger CM and Levy BI . (2001). Circ. Res., 89, 678–683.

  • Simpson K and Jarvis B . (2000). Drugs, 59, 1149–1167.

  • Skopinski P, Sommer E, Borowska A, Hevelke A, Rogala E and Skopinska-Rozewska E . (2001). Int. J. Clin. Pharmacol. Res., 21, 73–78.

  • Skovronsky D, Path S, Lee VM and Milla ME . (2001). J. Neurobiol., 49, 40–46.

  • Slack B, Ma LK and Seah CC . (2001). Biochem. J., 357, 787–794.

  • Soderstrom M, Aro HT, Ahonen M, Johansson N, Aho A, Ekfors T, Bohling T, Kahari VM and Vuorio E . (2001). APMIS, 109, 305–315.

  • Spinale FG, Coker ML, Bond BR and Zellner JL . (2000). Cardiovasc. Res., 46, 225–238.

  • Sunderkotter C, Steinbrink K, Goebeler M, Bhardwaj R and Sorg C . (1994). J. Leukoc. Biol., 55, 410–422.

  • Takeshita S, Tomiyama H, Yokoyama N, Kawamura Y, Furukawa T, Ishiggai Y, Shibano T, Isshiki T and Sato T . (2001). Cardiovasc. Res., 52, 314–320.

  • Thathiah A, Blobel CP and Carson DD . (2003). J. Biol. Chem., 278, 3386–3394.

  • Tomanek R and Schatteman GC . (2000). Anat. Rec., 261, 126–135.

  • Toth M, Hernandez-Barrantes S, Osenkowski P, Bernardo MM, Gervasi DC, Shimura Y, Meroueh O, Kotra LP, Galvez BG, Arroyo AG, Mobashery S and Fridman R . (2002). J. Biol. Chem., 277, 26340–26350.

  • Trifilieff A, Walker C, Keller T, Kottirsch G and Neumann U . (2002). Br. J. Pharmacol., 135, 1655–1664.

  • Tschesche H, Lichte A, Hiller O, Oberpichler A, Buttner FH and Bartnik E . (2000). Adv. Exp. Med. Biol., 477, 217–228.

  • Ueno H, Nakamura H, Inoue M, Imai K, Noguchi M, Sato H, Seiki M and Okada Y . (1997). Cancer Res., 57, 2055–2060.

  • Vivian EM and Rubinstein GB . (2002). Clin. Ther., 24, 1741–1756.

  • Volpert OV, Ward WF, Lingen MW, Chesler L, Solt DB, Johnson MD, Molteni A, Polverini PJ and Bouck NP . (1996). J. Clin. Invest., 98, 671–679.

  • Vranes D, Dilley RJ and Cooper ME . (1995). J. Diabetes Compl., 9, 296–300.

  • Wang DH and Prewitt RL . (1990). Hypertension, 15, 68–77.

  • Wesley U, Albino AP, Tiwari S and Houghton AN . (1999). J. Exp. Med., 190, 311–322.

  • Wright JW, Amir HZ, Murray CE, Roberts KA, Harding JW, Mizutani S and Ward PE . (1991). Brain Res. Bull., 27, 545–551.

  • Xu P, Alfaidy N and Challis JR . (2002). J. Clin. Endocrinol. Metab., 87, 1353–1361.

  • Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR and Decicco CP . (2001). J. Med. Chem., 44, 2636–2660.

  • Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N and Matsuura K . (1999). Immunol. Today, 20, 278–284.

  • Yamanaka H, Makino K, Takizawa M, Nakamura H, Fujimoto N, Moriya H, Nemori R, Sato H, Seiki M and Okada Y . (2000). Lab. Invest., 80, 677–687.

  • Yoshiji H, Kuriyama S, Kawata M, Yoshiji J, Ikenaka Y, Noguchi R, Nakatani T, Tsujinoue H and Fukui H . (2001). Clin. Cancer Res., 7, 1073–1078.

  • Yoshiji H, Yoshi J, Ikenaka Y, Noguchi R, Yanase K, Tsujinoue H, Imazu H and Fukui H . (2002a). Int. J. Oncol, 20, 1227–1231.

  • Yoshiji H, Kuriyama S and Fukui H . (2002b). Anti-cancer Drugs, 13, 221–228.

  • Yu Q and Stamenkovic I . (1999). Genes Dev., 13, 35–48.

  • Zhang X, De Meester I, Lambeir AM, Dillen L, Van Dongen W, Esmans EL, Haemers A, Scharpe S and Claeys M . (1999). J. Mass Spectrom., 34, 255–263.

  • Zhao J, Chen H, Peschon JJ, Shi W, Zhang Y, Frank SJ and Warburton D . (2001). Dev. Biol., 232, 204–218.

  • Zini S, Fournie-Zaluski MC, Chauvel E, Roques B, Corvol P and LLorens-Cortes C . (1996). Proc. Natl. Acad. Sci. USA, 93, 11968–11973.

  • Zhou Z, Apte SS, Soinen R, Cao R, Baaklini GY, Rauser RW, Wang J, Cao Y and Tryggvason K . (2000). Proc. Natl. Acad. Sci., 97, 4052–4057.

  • Zukowska-Grojec Z, Karwatowska-Prokopczuk E, Rose W, Rone J, Movafagh S, Ji H, Yeh Y, Chen W, Kleinman HK, Grouzmann E and Grant DS . (1998). Circ. Res., 83, 187–195.

  • Zukowska Z, Pons J, Lee EW and Li L . (2003). Can. J. Physiol. Pharmacol., 81, 89–94.

Download references

Acknowledgements

This review is dedicated to the late Dr John Kenny (1924–2002), who stood out as a scientist of great intellectual generosity. Historically, the considerable advances in our understanding of ectopeptidases resulting from Dr Kenny's research over many years have brought these enzymes to the attention of a wide range of scientists in many different disciplines (‘Cell-surface peptidases as modulators of growth and differentiation’ by AJ Kenny, MJ O'hare and BA Gusterson, 1989, The Lancet 2, 785–787). I am grateful to Dr John Woodley (Faculté des Sciences Pharmaceutiques, Toulouse, France) for a critical review of the manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brigitte Bauvois.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bauvois, B. Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis?. Oncogene 23, 317–329 (2004). https://doi.org/10.1038/sj.onc.1207124

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1207124

Keywords

This article is cited by

Search

Quick links