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Loss of heterozygosity of the polymorphic PIG3 microsatellite with low frequency in de novo acute myeloid leukemias

Leukemia volume 18, pages 1148–1149 (2004)Cite this article

TO THE EDITOR

The p53 tumor suppressor is a transcription factor, which in response to various types of genotoxic stresses transactivates a number of genes by binding to specific DNA sequences. Somatic p53 mutations are the most frequent genetic alterations in human cancer. p53 mutations are uncommon in de novo acute myeloid leukemia (AML) and they seem to be restricted to particular cytogenetic subgroups with a very poor outcome.1

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Acknowledgements

This study was supported by the Fondo de Investigaciones Sanitarias (FIS) (PI020509, G03/008 and CO3/010).

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Authors and Affiliations

  1. Department of Hematology, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret, Barcelona, 167, Spain

    J F Nomdedéu, G Perea, C Estivill, A Lasa, S Brunet, A Aventín & J Sierra

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  1. J F Nomdedéu
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  2. G Perea
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Correspondence to J F Nomdedéu.

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Nomdedéu, J., Perea, G., Estivill, C. et al. Loss of heterozygosity of the polymorphic PIG3 microsatellite with low frequency in de novo acute myeloid leukemias. Leukemia 18, 1148–1149 (2004). https://doi.org/10.1038/sj.leu.2403379

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  • DOI: https://doi.org/10.1038/sj.leu.2403379

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