Elsevier

Kidney International

Volume 71, Issue 5, 1 March 2007, Pages 379-381
Kidney International

Commentary
The genetic susceptibility to IgA nephropathy: A novel functional candidate gene for incomplete O-glycosylation of IgA1

https://doi.org/10.1038/sj.ki.5002139Get rights and content
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Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy.

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