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Effects of weight loss on PLTP activity and HDL particle size

International Journal of Obesity volume 28, pages 1280–1282 (2004)Cite this article

Abstract

OBJECTIVE: Dyslipidaemia in obesity is characterized by hypertriglyceridaemia, low HDL-C levels, small, dense HDL particles and increased phospholipid transfer protein (PLTP) activity.

METHODS: In the present study, we investigated PLTP activity and HDL particle size in 16 morbidly obese, middle-aged women, who underwent Swedish Adjustable Gastric Banding surgery. Study subjects were tested within 2 months before and 1 y after surgery. PLTP activity was determined by exogenous substrate assay and HDL particle size by gradient gel electrophoresis, respectively.

RESULTS: Pronounced weight loss after gastric banding surgery resulted in a significant decrease of PLTP activity from 8.42±2.04 to 7.43±2.21 μmol/ml/h (P=0.02). The size of HDL2 particles increased signficantly from 14.04±0.86 to 14.28±0.64 nm (P=0.02) after body weight reduction, while no change in HDL3 particle size was apparent.

DISCUSSION: Our results suggest that dyslipidaemia in obesity is—at least partially—reversible by weight loss. We hypothesize that reduction of PLTP activity and increase of HDL particle size are important component factors in converting the atherogenic lipoprotein profile of obese subjects into a less atherogenic profile with weight loss.

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References

  1. Kaser S, Sandhofer A, Foger B, Ebenbichler CF, Igelseder B, Malaimare L, Paulweber B, Patsch JR . Influence of obesity and insulin sensitivity on phospholipid transfer protein activity. Diabetologia 2001; 44: 1111–1117.

    Article  CAS  Google Scholar 

  2. Jauhiainen M, Metso J, Pahlman R, Blomqvist S, van Tol A, Ehnholm C . Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J Biol Chem 1993; 268: 4032–4036.

    CAS  Google Scholar 

  3. van Haperen R, van Tol A, Vermeulen P, Jauhiainen M, van Gent T, van den Berg P, Ehnholm S, Grosveld F, van der Kamp A, de Crom R . Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice. Arterioscler Thromb Vasc Biol 2000; 20: 1082–1088.

    Article  CAS  Google Scholar 

  4. Foger B, Santamarina-Fojo S, Shamburek RD, Parrot CL, Talley GD, Brewer Jr HB . Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL. J Biol Chem 1997; 272: 24700–27393.

    Article  Google Scholar 

  5. Ebenbichler CF, Laimer M, Kaser S, Ritsch A, Sandhofer A, Weiss H, Aigner F, Patsch JR . Relationship between cholesteryl ester transfer protein and atherogenic lipoprotein profile in morbidly obese women. Arterioscler Thromb Vasc Biol 2002; 22: 1465–1469.

    Article  CAS  Google Scholar 

  6. Blanche PJ, Gong EL, Forte TM, Nichols AV . Characterization of human high-density lipoproteins by gradient gel electrophoresis. Biochim Biophys Acta 1981; 665: 408–419.

    Article  CAS  Google Scholar 

  7. Huuskonen J, Olkkonen VM, Jauhiainen M, Ehnholm C . The impact of phospholipid transfer protein (PLTP) on HDL metabolism. Atherosclerosis 2001; 155: 269–281.

    Article  CAS  Google Scholar 

  8. Freedman DS, Otvos JD, Jeyarajah EJ, Barboriak JJ, Anderson AJ, Walker JA . Relation of lipoprotein subclasses as measured by proton nuclear magnetic resonance spectroscopy to coronary artery disease. Arterioscler Thromb Vasc Biol 1998; 18: 1046–1053.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinical Department of General Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria

    S Kaser, M Laimer, A Sandhofer, K Salzmann, C F Ebenbichler & J R Patsch

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  1. S Kaser
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  2. M Laimer
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  3. A Sandhofer
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  4. K Salzmann
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  5. C F Ebenbichler
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  6. J R Patsch
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Correspondence to J R Patsch.

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Kaser, S., Laimer, M., Sandhofer, A. et al. Effects of weight loss on PLTP activity and HDL particle size. Int J Obes 28, 1280–1282 (2004). https://doi.org/10.1038/sj.ijo.0802764

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  • DOI: https://doi.org/10.1038/sj.ijo.0802764

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