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Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women

International Journal of Obesity volume 27, pages 896–900 (2003)Cite this article

Abstract

BACKGROUND: The human adiponectin gene has been implicated in the pathophysiology of obesity, type II diabetes mellitus, dyslipidemia and atherosclerosis. Investigation of the physiological functions of the adiponectin gene in humans was mainly conducted at the levels of plasma proteins or DNA polymorphisms. The depot-specific adiponectin mRNA levels also could be relevant to these physiological functions.

OBJECTIVES: The relation between the adipose depot-specific adiponectin mRNA expression levels and various metabolic factors, including BMI, fasting plasma glucose, insulin, triglycerides (TGs) and HDL-cholesterol and insulin resistance index by HOMA, was investigated among 66 nondiabetic women using quantitative real-time PCR.

RESULTS: The subcutaneous relative adiponectin mRNA levels (SRAmR) correlated significantly with the omental relative adiponectin mRNA levels (ORAmR) (γ=0.468, P=0.0001). The SRAmR correlated inversely with the fasting plasma glucose with a borderline significance (γ=−0.35, P=0.058). On the other hand, the ORAmR correlated negatively with serum TG levels with the adjustment for age (γ=−0.33, P=0.007) or age plus BMI (γ=−0.27, P=0.027).

CONCLUSION: These results indicate that the adiponectin mRNA levels in different adipose depots were at least related to certain phenotypes of metabolic syndrome. The expression levels of adiponectin in the omental adipose depots are related to TG metabolism.

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Acknowledgements

We thank Ms Jao-Ping Wang for her technical assistance. This work was supported in part by a grant from the Ministry of Education (89-B-FA01-1-4) of Taiwan.

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  1. W-S Yang and M-H Chen: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

    W-S Yang, K-C Lee, C-L Chao, T-Y Tai & L-M Chuang

  2. Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei Hsien, Taiwan

    M-H Chen

  3. Department of Surgery, En-Chu-Kong Hospital, Taipei Hsien, Taiwan

    W-J Lee

  4. Department of Family Medicine, National Taiwan University Hospital, Taipai, Taiwan

    K-C Huang

  5. Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan

    C-L Chen

  6. Graduate Institute of Clinical Medicine, College of Medicine, Taiwan

    W-S Yang & L-M Chuang

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  1. W-S Yang
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Correspondence to L-M Chuang.

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Yang, WS., Chen, MH., Lee, WJ. et al. Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women. Int J Obes 27, 896–900 (2003). https://doi.org/10.1038/sj.ijo.0802367

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