Abstract
Objectives: To investigate total daily energy expenditure in chronic obstructive pulmonary disease (COPD) patients during a rehabilitation programme.
Design: Observational study involving a case and a control group.
Subjects: Ten COPD patients (six with body mass index (BMI) <18.5 kg/m2 and four with BMI >18.5 kg/m2) were evaluated for their energy expenditure profile. Four additional healthy age-matched volunteers were also included for methodology evaluation.
Interventions: Measurements of total daily energy expenditure (TEE), resting energy expenditure (REE) and diet-induced thermogenesis (DIT) and energy intake were undertaken by indirect calorimetry and bicarbonate–urea methods and dietary records.
Results: REE in COPD patients was not significantly different from that predicted by the Harris–Benedict equation. Before the exercise day the mean TEE was 1508 kcal/day and physical activity level (PAL as calculated by TEE/REE) was 1.52. On the exercise day the TEE increased to 1568 kcal/day and PAL was 1.60, but neither of these changes were significant. The energy cost of increased physical activity during rehabilitation exercise was estimated to be 191 kcal/day. No significant change was found in DIT between the two patient groups. However, overall energy balances were found to be negative (−363 kcal/day).
Conclusion: The rehabilitation programme did not cause a significant energy demand in COPD patients. TEE in COPD patients was not greater than in free-living healthy subjects. Patients, who were underweight, did not have a higher TEE than patients with normal weight. This suggested that malnutrition in COPD patients was not due to an increased energy expenditure. On the other hand, a significant negative energy balance due to insufficient energy intake was found in seven out of 10 patients.
Sponsorship: The project was inpart supported by the Bristol Myers Squibb Unrestricted Nutrition Grant.
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Tang, N., Chung, M., Elia, M. et al. Total daily energy expenditure in wasted chronic obstructive pulmonary disease patients. Eur J Clin Nutr 56, 282–287 (2002). https://doi.org/10.1038/sj.ejcn.1601299
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DOI: https://doi.org/10.1038/sj.ejcn.1601299
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