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Post-Transplant Events

Longitudinal follow-up of body composition in hematopoietic stem cell transplant patients

Bone Marrow Transplantation volume 35, pages 1171–1177 (2005)Cite this article

Summary:

Patients with hematological malignancies are well nourished prior to allogeneic hematopoietic stem cell transplantation (HSCT). HSCT and associated complications can affect body composition. The study evaluated cross-sectionally the prevalence and longitudinally the changes in lean body mass index (LBMI) in HSCT patients. Patients (n=82) were classified as normal or low LBMI. Logistic regression analyses were used to estimate odds ratios (OR) for low vs normal LBMI, between healthy volunteers and patients; for limited or extensive vs no chronic graft-versus-host-disease (GVHD); and for decreased (Karnofsky <80) vs normal functional status (>80). Patients were significantly more likely to have low LBMI at 6, 12 months, 2–3, 4–6 and >6 years than volunteers. In all, 38% of patients were below pre-HSCT LBMI at 4–6 years post-HSCT. Low LBMI was significantly associated with steroid treatment (OR 2.6, confidence intervals (CI) 1.3–5.2, P=0.008); limited (OR 5.5, CI 1.7–18.5, P=0.005) or extensive chronic GVHD (OR 20.3, CI 5.7–71.6, P<0.001); and decreased performance status (Karnofsky scores of ⩽80) (OR 2.7, CI 1.3–5.9, P=0.01). Patients were more likely to have low LBMI than volunteers. Chronic GVHD and low performance status were associated with low LBMI; thus, complications and/or treatment increase the likelihood of low LBMI.

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Acknowledgements

We thank the Foundation Nutrition 2000Plus for financial support.

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Authors and Affiliations

  1. Division of Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland

    U G Kyle, V L Karsegard & C Pichard

  2. Division of Hematology, Geneva University Hospital, Geneva, Switzerland

    Y Chalandon & C Helg

  3. Division of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland

    R Miralbell

  4. Division of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland

    D Hans

  5. Division of Bone Disease, Geneva University Hospital, Geneva, Switzerland

    A Trombetti & R Rizzoli

Authors
  1. U G Kyle
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  2. Y Chalandon
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  3. R Miralbell
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  4. V L Karsegard
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  6. A Trombetti
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  7. R Rizzoli
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  8. C Helg
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  9. C Pichard
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Correspondence to C Pichard.

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Kyle, U., Chalandon, Y., Miralbell, R. et al. Longitudinal follow-up of body composition in hematopoietic stem cell transplant patients. Bone Marrow Transplant 35, 1171–1177 (2005). https://doi.org/10.1038/sj.bmt.1704996

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  • DOI: https://doi.org/10.1038/sj.bmt.1704996

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