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Post transplant lymphoproliferative disease: detection of tumor by Tc99m sestaMIBI and treatment with rituximab

Bone Marrow Transplantation volume 35, pages 317–318 (2005)Cite this article

Post transplant lymphoproliferative disease (PTLD) is often difficult to diagnose because of nonspecific clinical features, and unusual and/or extranodal presentations.

A 40-year-old-man with acute lymphoblastic leukemia (ALL) underwent allogeneic peripheral blood stem cell transplantation (PBSCT) in December 2001. Cyclosporine and prednisolone were given for 8 months as GVHD prophylaxis. In April 2002, liver function tests were found to be abnormal. CMV Ag was positive. CMV hepatitis was suspected but the patient refused a liver biopsy, and he was treated with ganciclovir for 2 weeks. He was well until July 2003, when skin GVHD developed, which was treated with systemic steroids. At the end of July 2003, routine biochemical analysis showed hypergammaglobulinemia and elevated β2-microglobulin. Physical examination was negative except minimal skin excoriation over the extremities. Laboratory parameters were as follows: hemoglobin 11.5 g/dl, white blood cells 11.8 × 109/l, platelets 393 × 109/l, LDH 613 IU/l, AST 59 IU/l, total protein 9.1 g/dl, albumin 2.5 g/dl, β2-microglobulin 8.2 ng/dl and IgG 4911 mg/dL; PTLD was suspected.

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Authors and Affiliations

  1. Department of Oncology, Cukurova University Faculty of Medicine, Adana, Turkey

    S Paydas, U Disel & S Yavuz

  2. Department of Nuclear Medicine, Cukurova University Faculty of Medicine, Adana, Turkey

    Z Yapar & I B Guney

  3. Department of Pathology, Cukurova University Faculty of Medicine, Adana, Turkey

    M Ergin

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  1. S Paydas
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  2. Z Yapar
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Paydas, S., Yapar, Z., Ergin, M. et al. Post transplant lymphoproliferative disease: detection of tumor by Tc99m sestaMIBI and treatment with rituximab. Bone Marrow Transplant 35, 317–318 (2005). https://doi.org/10.1038/sj.bmt.1704794

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