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Isolated extramedullary relapse in the pleural fluid of a patient with acute myeloid leukemia following allogeneic BMT

Bone Marrow Transplantation volume 30, pages 57–59 (2002)Cite this article

Abstract

We report an unusual case of AML, in which the patient showed extramedullary relapse in the pleural fluid and the skin without bone marrow recurrence even 3 years after allogeneic BMT. On examination of the pleural effusion and the skin, which relapsed 31 months and 40 months, respectively, after BMT, we found that most of cells were as the XY-type recipient by quantitative X/Y FISH (fluorescence in situ hybridization). However, 100% of the bone marrow cells remained XX-type donor cells. In the present case, we believe that the graft-versus-leukemia (GVL) response in the extramedullary site was not so effective as that in the bone marrow, where it remains effective.

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Acknowledgements

Supported by a research grant from the Cancer Research Institute, Seoul National University (2002).

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Authors and Affiliations

  1. Department of Clinical Pathology, College of Medicine, Seoul National University, Seoul, Korea

    J Park, HI Cho & D Lee

  2. Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea

    D Lee

  3. Department of Internal Medicine, Seoul National University, Seoul, Korea

    SY Park

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  1. J Park
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  2. SY Park
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  3. HI Cho
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Park, J., Park, S., Cho, H. et al. Isolated extramedullary relapse in the pleural fluid of a patient with acute myeloid leukemia following allogeneic BMT. Bone Marrow Transplant 30, 57–59 (2002). https://doi.org/10.1038/sj.bmt.1703572

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  • DOI: https://doi.org/10.1038/sj.bmt.1703572

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