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Beneficial effect of intravenous lidocaine in cutaneous chronic graft-versus-host disease secondary to donor lymphocyte infusion

Bone Marrow Transplantation volume 28, pages 97–99 (2001)Cite this article

Abstract

We report two cases of refractory chronic graft-versus-host disease after donor lymphocyte infusions in which the skin lesions improved dramatically with the use of intravenous pulses of lidocaine. This form of therapy has been used successfully for the cutaneous involvement of scleroderma and may have vasodilator and anti-inflammatory effects. Bone Marrow Transplantation (2001) 28, 97–99.

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Acknowledgements

We are grateful to Dr Mary E Flowers for reviewing the manuscript, Ms Elisa Vendramini for assessing range of movements of patient 1, and for FAPESP (Proc 98/11981–0), CNPq, FAEPA/HCRP and FUNDHERP for financial support in Brazil.

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Authors and Affiliations

  1. Bone Marrow Transplantation Unit, University Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil

    JC Voltarelli, EJA Paton, A B P L Stracieri, M Coutinho & BP Simoes

  2. Blood and Marrow Transplant Division, University of California, San Diego School of Medicine, La Jolla, CA, USA

    H Ahmed, P Holman, A Bashey, ED Ball & E Carrier

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  1. JC Voltarelli
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  2. H Ahmed
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  3. EJA Paton
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  4. A B P L Stracieri
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  5. P Holman
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  6. A Bashey
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  7. M Coutinho
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  8. BP Simoes
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  9. ED Ball
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  10. E Carrier
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Voltarelli, J., Ahmed, H., Paton, E. et al. Beneficial effect of intravenous lidocaine in cutaneous chronic graft-versus-host disease secondary to donor lymphocyte infusion. Bone Marrow Transplant 28, 97–99 (2001). https://doi.org/10.1038/sj.bmt.1703080

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  • DOI: https://doi.org/10.1038/sj.bmt.1703080

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