Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Development of spontaneous factor VIII inhibitor in association with acute graft-versus-host disease

Bone Marrow Transplantation volume 27, pages 887–889 (2001)Cite this article

Abstract

A 57-year-old female with recurrent AML underwent a T cell-depleted (TCD) bone marrow (BM) plus TCD and CD34-selected peripheral blood stem cell (PBSC) transplant. Eleven weeks post transplantation, the patient developed acute graft-versus-host disease (GVHD) manifested by rash and elevated liver enzymes. Concurrently, the patient presented with a bleeding diathesis and a left forearm hematoma due to the development of a spontaneous factor VIII inhibitor. She was treated with human recombinant factor VIII and intravenous methylprednisolone. Subsequently she was managed with a prednisone taper leading to resolution of the GVHD, as well as the spontaneous factor VIII inhibitor. Bone marrow transplant-related spontaneous factor VIII inhibitor has previously been reported in association with one patient with chronic GVHD. To our knowledge this is the first report of spontaneous factor VIII inhibitor associated with acute GVHD. Bone Marrow Transplantation (2001) 27, 887–889.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Ferrara JLM, Deeg HJ . Graft-versus-host disease New Engl J Med 1991 324: 667–674

    Article  CAS  Google Scholar 

  2. O'Reilly RJ, Papadopoulos EB . Allogeneic transplantation In: Holland JF et al (eds) Cancer Medicine 4th edn: Lea-Febiger: Philadelphia 1997 pp 1295–1324

    Google Scholar 

  3. Biggs R . Human Blood Coagulation, Hemostasis and Thrombosis Blackwell Scientific Publications: Oxford 1972

    Google Scholar 

  4. Morrison AE, Ludlam CA . Acquired haemophilia and its management Br J Haematol 1995 89: 231–236

    Article  CAS  Google Scholar 

  5. Lusher JM . Factor VIII inhibitors: etiology, characterization, natural history, and management Ann NY Acad Sci 1987 509: 89–102

    Article  CAS  Google Scholar 

  6. White GC, McMillan CW, Blatt PM, Roberts HR . Factor VIII inhibitors: a clinical overview Am J Hematol 1982 13: 335–342

    Article  Google Scholar 

  7. Sohngen D, Specker C, Bach D et al. Acquired factor VIII inhibitors in nonhemophilic patients Ann Hematol 1997 74: 89–93

    Article  CAS  Google Scholar 

  8. Green D, Lechner K . A survey of 215 non-hemophilic patients with inhibitors to factor VIII Thromb Haemostas 1981 45: 200–203

    Article  CAS  Google Scholar 

  9. Seidler CW, Mills LE, Flowers MED, Sullivan KM . Spontaneous factor VIII occurring in association with chronic graft-versus-host disease Am J Hematol 1994 45: 240–243

    Article  CAS  Google Scholar 

  10. Greeno EW, Haake R, McGlave P et al. Lupus inhibitors following bone marrow transplant Bone Marrow Transplant 1995 15: 287–291

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hematology/Oncology Division, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    RJ Brentjens, L Reich & AA Jakubowski

  2. Hematology/Oncology Division, Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    L Smith

Authors
  1. RJ Brentjens
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L Reich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. AA Jakubowski
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brentjens, R., Smith, L., Reich, L. et al. Development of spontaneous factor VIII inhibitor in association with acute graft-versus-host disease. Bone Marrow Transplant 27, 887–889 (2001). https://doi.org/10.1038/sj.bmt.1703009

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703009

Keywords

This article is cited by

Search

Advanced search

Quick links