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Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein–Barr virus infection

Bone Marrow Transplantation volume 26, pages 805–808 (2000)Cite this article

Abstract

The prognosis of chronic active Epstein–Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality. Bone Marrow Transplantation (2000) 26, 805–808.

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Acknowledgements

We would like to thank Dr Keisei Kawa-H for critical advice of the treatment.

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Authors and Affiliations

  1. Department of Internal Medicine II, Okayama University Medical School, Okayama, Japan

    N Fujii, K Takenaka, A Hiraki, Y Maeda, K Ikeda, K Shinagawa, A Ashiba, M Munemasa, K Sunami, Y Hiramatsu, F Ishimaru, K Niiya & M Harada

  2. Department of Pathology II, Okayama University Medical School, Okayama, Japan

    M Munemasa & T Yoshino

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  1. N Fujii
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  2. K Takenaka
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Fujii, N., Takenaka, K., Hiraki, A. et al. Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein–Barr virus infection. Bone Marrow Transplant 26, 805–808 (2000). https://doi.org/10.1038/sj.bmt.1702600

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  • DOI: https://doi.org/10.1038/sj.bmt.1702600

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