Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Factor V Leiden mutation as a predisposing factor for veno-occlusive disease following BMT

Bone Marrow Transplantation volume 25, pages 1110–1111 (2000)Cite this article

In a recent issue of this journal, Duggan et al1 retrospectively evaluated the importance of factor V Leiden (1691 G-A) and the prothrombin gene 20210 G-A mutations as a predisposing factor for veno-occlusive disease (VOD) following BMT. In their study, 15 of the 22 patients who developed VOD and 51 patients without VOD following BMT were evaluated. The authors concluded that the prothrombin gene 20210 G-A but not factor V Leiden mutation may increase the risk of VOD in BMT patients but also that prospective confirmation with larger studies is needed. We would like to share our experience which is in contrast with the conclusion of this study.

In December 1997, we initiated a prospective study in children, looking at the association of inherited abnormalities known to predispose to thrombosis and VOD following BMT. VOD was diagnosed on the basis of clinical criteria, as previously described,2 similar to Duggan et al’s study. Severity of VOD was scored as mild, moderate or severe as previously defined.2 The laboratory evaluation of inherited hypercoagulable abnormalities included functional anticoagulant assays for protein C, protein S, antithrombin III (ATIII), factor VIII and genetic analysis of the factor V Leiden and prothrombin 20210 G-A mutation before conditioning therapy. Genetic analyses were performed as previously described.34

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Duggan C, Schmidt M, Lawler M et al. The prothrombin gene variant G20210A but not factor V Leiden may be associated with veno-occlusive disease following BMT Bone Marrow Transplant 1999 24: 693–694

    Article  CAS  PubMed  Google Scholar 

  2. McDonald GB, Hinds MS, Fisher LD et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients Ann Intern Med 1993 118: 255–267

    Article  CAS  PubMed  Google Scholar 

  3. Akar N, Akar E, Dalgın G et al. Frequency of factor V (1691 G-A) mutation in Turkish population Thromb Haemost 1997 78: 1527–1528

    Article  CAS  PubMed  Google Scholar 

  4. Akar N, Mısırlıoğlu M, Akar E et al. Prothrombin gene 20210 G-A mutation in the Turkish population Am J Hematol 1998 58: 249

    Article  CAS  PubMed  Google Scholar 

  5. Faioni EM, Krachmalnicoff A, Bearman SI et al. Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venoocclusive disease of liver Blood 1993 81: 3458–3462

    CAS  PubMed  Google Scholar 

  6. Attal M, Huguet F, Rubie H et al. Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial Blood 1992 79: 2834–2840

    CAS  PubMed  Google Scholar 

  7. Bearman SI, Lee JL, Baron AE, McDonald GB . Treatment of hepatic venocclusive disease with recombinant human tissue plasminogen activator and heparin in 42 marrow transplant patients Blood 1997 89: 1501–1506

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Hematology, Ankara University School of Medicine, Dikimevi, Ankara, 06100, Turkey

    M Ertem & N Akar

Authors
  1. M Ertem
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N Akar
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ertem, M., Akar, N. Factor V Leiden mutation as a predisposing factor for veno-occlusive disease following BMT. Bone Marrow Transplant 25, 1110–1111 (2000). https://doi.org/10.1038/sj.bmt.1702390

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702390

This article is cited by

Search

Advanced search

Quick links