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Cancer therapy

A cFLIP-flop switch for senolysis

Nature Cancer volume 3, pages 1279–1281 (2022)Cite this article

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Persistent senescent cancer cells have tumor-promoting potential, making their selective elimination a prime therapeutic objective. The death receptor inhibitor cFLIP has now been shown to counter the susceptibility of senescent cells to DR5-mediated extrinsic apoptosis, which can be therapeutically exploited.

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Fig. 1: The NF-κB-governed cFLIP-flop state switch between death and survival in TIS.

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Authors and Affiliations

  1. Medical Department of Hematology, Oncology and Tumor Immunology, Charité–Universitätsmedizin Berlin, Molekulares Krebsforschungszentrum, Berlin, Germany

    Dorothy N. Y. Fan & Clemens A. Schmitt

  2. Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

    Clemens A. Schmitt

  3. Johannes Kepler University, Linz, Austria

    Clemens A. Schmitt

  4. Department of Hematology and Oncology, Kepler University Hospital, Linz, Austria

    Clemens A. Schmitt

  5. Deutsches Konsortium für Translationale Krebsforschung, Berlin, Germany

    Clemens A. Schmitt

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  1. Dorothy N. Y. Fan
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  2. Clemens A. Schmitt
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Correspondence to Clemens A. Schmitt.

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Fan, D.N.Y., Schmitt, C.A. A cFLIP-flop switch for senolysis. Nat Cancer 3, 1279–1281 (2022). https://doi.org/10.1038/s43018-022-00455-1

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